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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei239ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-2938-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:CPS_3216
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002373541 – 470Glutamate--tRNA ligaseAdd BLAST470

Proteomic databases

PRIDEiQ47Z58

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_3216

Structurei

3D structure databases

ProteinModelPortaliQ47Z58
SMRiQ47Z58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi236 – 240"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q47Z58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLTTRFAPS PTGYLHVGGA RTALYSWLYA KKNGGDFILR IEDTDLERST
60 70 80 90 100
QASVDAIMDG MNWLNLEWTH GPYFQTERFD RYNEAIEQLI ASGNAYRCYS
110 120 130 140 150
TSEEVDAMRE EAKAKGEIEK YNGLWRDRTD HPADKPFVIR FKNPLEGDVI
160 170 180 190 200
IKDMVKGDIA ISNGQLDDLI IARSDGTPTY NLTVVVDDWD MKVSHVVRGD
210 220 230 240 250
DHVSNTPKQI NILRALGADV PQYAHIPMIL GDDGKRLSKR HGAVGVMQYR
260 270 280 290 300
DDGFLPEALL NYLVRLGWSH GDQEIFSREE MIELFDLKDC NRAPSGFNTD
310 320 330 340 350
KLIWVNQHYM KTMDPAYVAE HLAWHMADQG INTENGPALA DVVRIQADRV
360 370 380 390 400
KTLKEMADIS RYFYEDFTEL DAKAVKKHLR PVVKEPMILV KEKLAALTDW
410 420 430 440 450
SPEPIHAAIN DTAVELELGM GKVGMPLRVA ATGGGNSPSL DITLALLDQS
460 470
KVIERIEQAL VVVEARIAAG
Length:470
Mass (Da):52,732
Last modified:September 13, 2005 - v1
Checksum:iB0BFB1281A011994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ25341.1
RefSeqiWP_011043999.1, NC_003910.7

Genome annotation databases

EnsemblBacteriaiAAZ25341; AAZ25341; CPS_3216
KEGGicps:CPS_3216

Similar proteinsi

Entry informationi

Entry nameiSYE_COLP3
AccessioniPrimary (citable) accession number: Q47Z58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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