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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99ElectrophileUniRule annotation1
Active sitei171Proton acceptorUniRule annotation1
Binding sitei177Substrate; via amide nitrogenUniRule annotation1
Binding sitei216SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-3141-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:CPS_3448
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964901 – 256Triosephosphate isomeraseAdd BLAST256

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_3448.

Structurei

3D structure databases

ProteinModelPortaliQ47YJ8.
SMRiQ47YJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 12Substrate bindingUniRule annotation3
Regioni237 – 238Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CP7. Bacteria.
COG0149. LUCA.
HOGENOMiHOG000226413.
KOiK01803.
OMAiLCVGEGL.
OrthoDBiPOG091H02GL.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR035990. TIM_sf.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47YJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQAIVAAN WKMNGDSALV DTMVSGLADI ELSSHVDVVI CPSFPYLSEL
60 70 80 90 100
NQKIKAANLN EAIHVGSQNV SEHESGAYTG EVSTAMLQNL AINYVIVGHS
110 120 130 140 150
ERRSIFKETS TQVAKKVHAA LNAGLTPILC IGESEAERAT GETETVLSAQ
160 170 180 190 200
IQPVIDEIGI EKFKDVVIAY EPVWAIGTGK TASSAMAQET HQFIRKFLAQ
210 220 230 240 250
QNEQVADKVP LLYGGSVNAA NCEELFAQTD IDGGLIGGAS LKAEQFKIIC

SAAKGK
Length:256
Mass (Da):27,335
Last modified:September 13, 2005 - v1
Checksum:i5FB37DA6E0AFFF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ27096.1.
RefSeqiWP_011044208.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ27096; AAZ27096; CPS_3448.
KEGGicps:CPS_3448.

Similar proteinsi

Entry informationi

Entry nameiTPIS_COLP3
AccessioniPrimary (citable) accession number: Q47YJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome