Reviewed, UniProtKB/Swiss-Prot Q47XG4 (GLYA3_COLP3)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 3
      Short name=Serine methylase 3
      Short name=SHMT 3
    EC=2.1.2.1

Gene names

Name:	glyA3
Ordered Locus Names:	CPS_3844

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Serine hydroxymethyltransferase 3 HAMAP MF_00051		PRO_0000234969
Amino acid modifications
	Modified residue	240	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47XG4-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 22E218284DF02BE0	FASTA	431	46,240
	10 20 30 40 50 60 MKNTYTSGEL EQFFSSDLSS TDGAVQVAID LEEARQNQQI ELIASENIVS KAVMEAQGTV 70 80 90 100 110 120 LTNKYAEGYP GRRYYGGCEH VDLVETLAID RAKLIFKADF VNVQPHSGAQ ANGAVMLALV 130 140 150 160 170 180 KPGDTILGMS LDAGGHLTHG AKPAQSGKWF NAIHYGVRKD DMRIDYDQVL ALAIEHQPKM 190 200 210 220 230 240 IIAGGSAIPR QIDFAKFREI ADQVGAILMV DMAHIAGLVA AGAHQNPLPF ADVVTTTTHK 250 260 270 280 290 300 TLRGPRGGLI LTNNPDVAKK INSAVFPGLQ GGPLMHVIAA KAVALGEVLE PSFGAYIKQV 310 320 330 340 350 360 LSNARVLAST LQQRGCDIVT DGTDTHLMLV DLRPKGLKGN TTEESLERAG ITCNKNGIPF 370 380 390 400 410 420 DSEKPMVTSG IRLGTPAGTS RGFGNDEFEL IGQWIGDVLD GLVANPEDNS VAEQKVLQQV 430 QQLCLRFPLY S

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ23994.1.
RefSeq	YP_270506.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q47XG4.
Genome annotation databases
GeneID	3518659.
GenomeReviews	Gene locus CPS_3844 in contig CP000083_GR.
KEGG	cps:CPS_3844.
NMPDR	fig|167879.3.peg.3334.
TIGR	CPS_3844.
Phylogenomic databases
HOGENOM	Q47XG4.
OMA	QGGPLEN.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_3844-MON.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA3_COLP3

Accession

Primary (citable) accession number: Q47XG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)