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Q47XG2 (GCSP2_COLP3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene names
Name:gcvP2
Ordered Locus Names:CPS_3846
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Glycine dehydrogenase (decarboxylating) 2 HAMAP-Rule MF_00711
PRO_0000227101

Amino acid modifications

Modified residue7061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47XG2 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: B37425159D3F1048

FASTA956105,128
        10         20         30         40         50         60 
MTNNNLLAQL NDNLDFISRH NGPDRTQQQH MLDTLKVDSI EQMIDKTVPD NIRLLQPMAL 

        70         80         90        100        110        120 
AKPQSEIEML ATLKGIASKN KVNRSYIGQG YYDTHVPHVI LRNVFENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
ISQGRLEALL NFQQMITDLT AMELSNASLL DEATAAAEAM SLCKRASKNK SNVFFVSDDV 

       190        200        210        220        230        240 
HPQTLDVINT RAKYFSFEVV VAPCSELENH DVFGALLQYP GTTGQVHNLE KIIEQAHSKK 

       250        260        270        280        290        300 
TLVAVAADLL ALTVLKAPGE MGADVVIGSA QRFGVPMGYG GPHAAFMATK EKYKRTIPGR 

       310        320        330        340        350        360 
VIGVSIDSKG KPALRMAMQT REQHIRREKA NSNICTAQAL LANMASFYAV YHGPQGLRKM 

       370        380        390        400        410        420 
GRRVNRLTSV LAAGLQKAGI ELVHNDFFDT ITLQTNEKTD AIYQRALAAD LNLRLLPDQL 

       430        440        450        460        470        480 
GISLDETTTS ADVEALWLAI TEQSFNVDDI EQTLSAEFCN IPADCQRTSE YLSHPVFNSY 

       490        500        510        520        530        540 
HSETRMLRYL KSLENKDFSL THGMIPLGSC TMKLNATAQM IPVTWPEFSR MHPFAPSDQC 

       550        560        570        580        590        600 
TGYETLAESF SDMLIEITGY DAFSLQPNSG AQGEYAGLIA IQRYHASRGE DYRNICLIPS 

       610        620        630        640        650        660 
SAHGTNPASA SMVSMRIVLV NCDKEGNVDL DDLKEKINLH RDQLSAMMIT YPSTHGVYEE 

       670        680        690        700        710        720 
SIKEICELIH EAGGQVYLDG ANMNAQVGLT SPGFIGADVS HLNLHKTFCI PHGGGGPGMG 

       730        740        750        760        770        780 
PIGVKSHLAD FLPGHSVTNT VGAVSATALG SASILPISWA YIALMGAEGL KSATELAILN 

       790        800        810        820        830        840 
ANYIMEKLSP HYPILFRGKQ GRVAHECIID LRPLKESSGI SEEDVAKRLM DFGFHAPTMS 

       850        860        870        880        890        900 
FPVAGTLMIE PTESESLEEL DKFIDALITI RHEIAKVEEG TWTLADNPLV NAPHTLNDLT 

       910        920        930        940        950 
GSDWPRAYSR LTACYPSSCP SQPKFWPTTN RIDNVYGDRN LICSCPPIES YQSTDT 

« Hide

References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000083 Genomic DNA. Translation: AAZ27773.1.
RefSeqYP_270508.1. NC_003910.7.

3D structure databases

ProteinModelPortalQ47XG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167879.CPS_3846.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ27773; AAZ27773; CPS_3846.
GeneID3522032.
KEGGcps:CPS_3846.
PATRIC21470599. VBIColPsy94388_3488.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHTQVDLM.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycCPSY167879:GI48-3846-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP2_COLP3
AccessionPrimary (citable) accession number: Q47XG2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families