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Q47XG2

- GCSP2_COLP3

UniProt

Q47XG2 - GCSP2_COLP3

Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-3846-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein 2UniRule annotation
    Glycine decarboxylase 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) 2UniRule annotation
    Gene namesi
    Name:gcvP2UniRule annotation
    Ordered Locus Names:CPS_3846
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956Glycine dehydrogenase (decarboxylating) 2PRO_0000227101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei706 – 7061N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi167879.CPS_3846.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47XG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q47XG2-1 [UniParc]FASTAAdd to Basket

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    MTNNNLLAQL NDNLDFISRH NGPDRTQQQH MLDTLKVDSI EQMIDKTVPD    50
    NIRLLQPMAL AKPQSEIEML ATLKGIASKN KVNRSYIGQG YYDTHVPHVI 100
    LRNVFENPGW YTAYTPYQPE ISQGRLEALL NFQQMITDLT AMELSNASLL 150
    DEATAAAEAM SLCKRASKNK SNVFFVSDDV HPQTLDVINT RAKYFSFEVV 200
    VAPCSELENH DVFGALLQYP GTTGQVHNLE KIIEQAHSKK TLVAVAADLL 250
    ALTVLKAPGE MGADVVIGSA QRFGVPMGYG GPHAAFMATK EKYKRTIPGR 300
    VIGVSIDSKG KPALRMAMQT REQHIRREKA NSNICTAQAL LANMASFYAV 350
    YHGPQGLRKM GRRVNRLTSV LAAGLQKAGI ELVHNDFFDT ITLQTNEKTD 400
    AIYQRALAAD LNLRLLPDQL GISLDETTTS ADVEALWLAI TEQSFNVDDI 450
    EQTLSAEFCN IPADCQRTSE YLSHPVFNSY HSETRMLRYL KSLENKDFSL 500
    THGMIPLGSC TMKLNATAQM IPVTWPEFSR MHPFAPSDQC TGYETLAESF 550
    SDMLIEITGY DAFSLQPNSG AQGEYAGLIA IQRYHASRGE DYRNICLIPS 600
    SAHGTNPASA SMVSMRIVLV NCDKEGNVDL DDLKEKINLH RDQLSAMMIT 650
    YPSTHGVYEE SIKEICELIH EAGGQVYLDG ANMNAQVGLT SPGFIGADVS 700
    HLNLHKTFCI PHGGGGPGMG PIGVKSHLAD FLPGHSVTNT VGAVSATALG 750
    SASILPISWA YIALMGAEGL KSATELAILN ANYIMEKLSP HYPILFRGKQ 800
    GRVAHECIID LRPLKESSGI SEEDVAKRLM DFGFHAPTMS FPVAGTLMIE 850
    PTESESLEEL DKFIDALITI RHEIAKVEEG TWTLADNPLV NAPHTLNDLT 900
    GSDWPRAYSR LTACYPSSCP SQPKFWPTTN RIDNVYGDRN LICSCPPIES 950
    YQSTDT 956
    Length:956
    Mass (Da):105,128
    Last modified:September 13, 2005 - v1
    Checksum:iB37425159D3F1048
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ27773.1.
    RefSeqiWP_011044594.1. NC_003910.7.
    YP_270508.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ27773; AAZ27773; CPS_3846.
    GeneIDi3522032.
    KEGGicps:CPS_3846.
    PATRICi21470599. VBIColPsy94388_3488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ27773.1 .
    RefSeqi WP_011044594.1. NC_003910.7.
    YP_270508.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q47XG2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_3846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ27773 ; AAZ27773 ; CPS_3846 .
    GeneIDi 3522032.
    KEGGi cps:CPS_3846.
    PATRICi 21470599. VBIColPsy94388_3488.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CPSY167879:GI48-3846-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681.

    Entry informationi

    Entry nameiGCSP2_COLP3
    AccessioniPrimary (citable) accession number: Q47XG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3