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Q47XG2

- GCSP2_COLP3

UniProt

Q47XG2 - GCSP2_COLP3

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Protein
Glycine dehydrogenase (decarboxylating) 2
Gene
gcvP2, CPS_3846
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPSY167879:GI48-3846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:gcvP2
Ordered Locus Names:CPS_3846
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Glycine dehydrogenase (decarboxylating) 2UniRule annotation
PRO_0000227101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi167879.CPS_3846.

Structurei

3D structure databases

ProteinModelPortaliQ47XG2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47XG2-1 [UniParc]FASTAAdd to Basket

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MTNNNLLAQL NDNLDFISRH NGPDRTQQQH MLDTLKVDSI EQMIDKTVPD    50
NIRLLQPMAL AKPQSEIEML ATLKGIASKN KVNRSYIGQG YYDTHVPHVI 100
LRNVFENPGW YTAYTPYQPE ISQGRLEALL NFQQMITDLT AMELSNASLL 150
DEATAAAEAM SLCKRASKNK SNVFFVSDDV HPQTLDVINT RAKYFSFEVV 200
VAPCSELENH DVFGALLQYP GTTGQVHNLE KIIEQAHSKK TLVAVAADLL 250
ALTVLKAPGE MGADVVIGSA QRFGVPMGYG GPHAAFMATK EKYKRTIPGR 300
VIGVSIDSKG KPALRMAMQT REQHIRREKA NSNICTAQAL LANMASFYAV 350
YHGPQGLRKM GRRVNRLTSV LAAGLQKAGI ELVHNDFFDT ITLQTNEKTD 400
AIYQRALAAD LNLRLLPDQL GISLDETTTS ADVEALWLAI TEQSFNVDDI 450
EQTLSAEFCN IPADCQRTSE YLSHPVFNSY HSETRMLRYL KSLENKDFSL 500
THGMIPLGSC TMKLNATAQM IPVTWPEFSR MHPFAPSDQC TGYETLAESF 550
SDMLIEITGY DAFSLQPNSG AQGEYAGLIA IQRYHASRGE DYRNICLIPS 600
SAHGTNPASA SMVSMRIVLV NCDKEGNVDL DDLKEKINLH RDQLSAMMIT 650
YPSTHGVYEE SIKEICELIH EAGGQVYLDG ANMNAQVGLT SPGFIGADVS 700
HLNLHKTFCI PHGGGGPGMG PIGVKSHLAD FLPGHSVTNT VGAVSATALG 750
SASILPISWA YIALMGAEGL KSATELAILN ANYIMEKLSP HYPILFRGKQ 800
GRVAHECIID LRPLKESSGI SEEDVAKRLM DFGFHAPTMS FPVAGTLMIE 850
PTESESLEEL DKFIDALITI RHEIAKVEEG TWTLADNPLV NAPHTLNDLT 900
GSDWPRAYSR LTACYPSSCP SQPKFWPTTN RIDNVYGDRN LICSCPPIES 950
YQSTDT 956
Length:956
Mass (Da):105,128
Last modified:September 13, 2005 - v1
Checksum:iB37425159D3F1048
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ27773.1.
RefSeqiWP_011044594.1. NC_003910.7.
YP_270508.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ27773; AAZ27773; CPS_3846.
GeneIDi3522032.
KEGGicps:CPS_3846.
PATRICi21470599. VBIColPsy94388_3488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ27773.1 .
RefSeqi WP_011044594.1. NC_003910.7.
YP_270508.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47XG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_3846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ27773 ; AAZ27773 ; CPS_3846 .
GeneIDi 3522032.
KEGGi cps:CPS_3846.
PATRICi 21470599. VBIColPsy94388_3488.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPSY167879:GI48-3846-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiGCSP2_COLP3
AccessioniPrimary (citable) accession number: Q47XG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi