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Q47XB8

- HISX1_COLP3

UniProt

Q47XB8 - HISX1_COLP3

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Protein
Histidinol dehydrogenase 1
Gene
hisD1, CPS_3890
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei329 – 3291Proton acceptor By similarity
Active sitei330 – 3301Proton acceptor By similarity
Binding sitei330 – 3301Substrate By similarity
Metal bindingi363 – 3631Zinc By similarity
Binding sitei363 – 3631Substrate By similarity
Binding sitei417 – 4171Substrate By similarity
Metal bindingi422 – 4221Zinc By similarity
Binding sitei422 – 4221Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCPSY167879:GI48-3890-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:CPS_3890
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenase 1UniRule annotation
PRO_0000135757Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_3890.

Structurei

3D structure databases

ProteinModelPortaliQ47XB8.
SMRiQ47XB8. Positions 3-432.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47XB8-1 [UniParc]FASTAAdd to Basket

« Hide

MINQLINWQE LSPQQKNSAL ARPAIADSAL LSTQVANILS QVKNQGDKAI    50
LALTEQFDGI ALSTLSVSSA QVAQAKLALT DKRLKAIHTA YKQIKSFHSA 100
QTASDITVET TPGVKCTLKT EAIESVGLYI PAGSAPLPST VLMLGVPAQL 150
TGCQRTVLVC PPDKNGQLAD EILVAADLCG ITEIYTVGGA QAIAALAYGT 200
ETIPAVNKVF GPGNRYVTEA KTQLSQQVAG FAIDMPAGPS EVLVIADGQA 250
NPAFIAADLL SQAEHGVDSQ VILLSDSESL ISKVSTEIAQ QLTLLSRCKI 300
AEQALKQSRL ILTKDLAQAV EVSNEYGPEH LIIQTEDAPT LLSKLRNAGS 350
IFVGAYTPES AGDYASGTNH VLPTYGYSKV ISSLSLADFS RRFTVQEITK 400
AGLQSLAECI IELTDAEGLD AHQRAVTIRL EEGS 434
Length:434
Mass (Da):45,853
Last modified:September 13, 2005 - v1
Checksum:iCD2635AFC75E5169
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ27302.1.
RefSeqiWP_011044638.1. NC_003910.7.
YP_270552.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ27302; AAZ27302; CPS_3890.
GeneIDi3521558.
KEGGicps:CPS_3890.
PATRICi21470677. VBIColPsy94388_3527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ27302.1 .
RefSeqi WP_011044638.1. NC_003910.7.
YP_270552.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47XB8.
SMRi Q47XB8. Positions 3-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_3890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ27302 ; AAZ27302 ; CPS_3890 .
GeneIDi 3521558.
KEGGi cps:CPS_3890.
PATRICi 21470677. VBIColPsy94388_3527.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CPSY167879:GI48-3890-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiHISX1_COLP3
AccessioniPrimary (citable) accession number: Q47XB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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