Reviewed, UniProtKB/Swiss-Prot Q47XB8 (HISX1_COLP3)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23

Gene names

Name:	hisD1
Ordered Locus Names:	CPS_3890

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Histidinol dehydrogenase 1 HAMAP MF_01024		PRO_0000135757
Sites
	Active site	329	1	Proton acceptor By similarity
	Active site	330	1	Proton acceptor By similarity
	Metal binding	262	1	Zinc By similarity
	Metal binding	265	1	Zinc By similarity
	Metal binding	363	1	Zinc By similarity
	Metal binding	422	1	Zinc By similarity
	Binding site	129	1	NAD By similarity
	Binding site	191	1	NAD By similarity
	Binding site	214	1	NAD By similarity
	Binding site	240	1	Substrate By similarity
	Binding site	262	1	Substrate By similarity
	Binding site	265	1	Substrate By similarity
	Binding site	330	1	Substrate By similarity
	Binding site	363	1	Substrate By similarity
	Binding site	417	1	Substrate By similarity
	Binding site	422	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47XB8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: CD2635AFC75E5169	FASTA	434	45,853
	10 20 30 40 50 60 MINQLINWQE LSPQQKNSAL ARPAIADSAL LSTQVANILS QVKNQGDKAI LALTEQFDGI 70 80 90 100 110 120 ALSTLSVSSA QVAQAKLALT DKRLKAIHTA YKQIKSFHSA QTASDITVET TPGVKCTLKT 130 140 150 160 170 180 EAIESVGLYI PAGSAPLPST VLMLGVPAQL TGCQRTVLVC PPDKNGQLAD EILVAADLCG 190 200 210 220 230 240 ITEIYTVGGA QAIAALAYGT ETIPAVNKVF GPGNRYVTEA KTQLSQQVAG FAIDMPAGPS 250 260 270 280 290 300 EVLVIADGQA NPAFIAADLL SQAEHGVDSQ VILLSDSESL ISKVSTEIAQ QLTLLSRCKI 310 320 330 340 350 360 AEQALKQSRL ILTKDLAQAV EVSNEYGPEH LIIQTEDAPT LLSKLRNAGS IFVGAYTPES 370 380 390 400 410 420 AGDYASGTNH VLPTYGYSKV ISSLSLADFS RRFTVQEITK AGLQSLAECI IELTDAEGLD 430 AHQRAVTIRL EEGS

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ27302.1.
RefSeq	YP_270552.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3521558.
GenomeReviews	Gene locus CPS_3890 in contig CP000083_GR.
KEGG	cps:CPS_3890.
NMPDR	fig|167879.3.peg.3530.
TIGR	CPS_3890.
Phylogenomic databases
HOGENOM	Q47XB8.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_3890-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX1_COLP3

Accession

Primary (citable) accession number: Q47XB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)