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Protein

Acetyl-coenzyme A synthetase

Gene

acs

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei309Coenzyme AUniRule annotation1
Binding sitei498ATPUniRule annotation1
Binding sitei513ATPUniRule annotation1
Binding sitei521Coenzyme A; via carbonyl oxygenUniRule annotation1
Binding sitei524ATPUniRule annotation1
Metal bindingi535Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi537Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi540Magnesium; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi385 – 387ATPUniRule annotation3
Nucleotide bindingi409 – 414ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-3607-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsImported
Synonyms:acsAUniRule annotation
Ordered Locus Names:CPS_3955Imported
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)Imported
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei607N6-acetyllysineUniRule annotation1

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_3955

Structurei

3D structure databases

ProteinModelPortaliQ47X57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 81ACAS_NInterPro annotationAdd BLAST57
Domaini84 – 520AMP-bindingInterPro annotationAdd BLAST437
Domaini529 – 607AMP-binding_CInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 194Coenzyme A bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IQF Bacteria
COG0365 LUCA
HOGENOMiHOG000229981
KOiK01895
OMAiVNCLDQH
OrthoDBiPOG091H059D

Family and domain databases

CDDicd05966 ACS, 1 hit
HAMAPiMF_01123 Ac_CoA_synth, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q47X57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELKSCYPV SEKAKAHTHI DAATYDAMYK KSIEQPDEFW GEQAKEFIDW
60 70 80 90 100
YKPWDSVSKV DLKNSEINWF SGGKLNVSYN CIDRHLATKA NDTAIIFEGD
110 120 130 140 150
DPNDDSKVTY QELHDHVCRF ANLLKERGVK KGDRVCIYMP MIPEVGYAML
160 170 180 190 200
ACARIGAIHS VVFGGFSTES IKARVLDADC KVVITADQSL RGGKRIPLKS
210 220 230 240 250
NVDAAVIDCP NVHSVIVVAR TGGDVAWNDK VDINYEEAVA KQSAICEPEV
260 270 280 290 300
MDAEDPLFVL YTSGSTGTPK GVVHTCGGYI LYAAMTHKYV FDYKEGEVYW
310 320 330 340 350
CTADAGWITG HSYIFYGPLA NGATTLVFEG VPTYPDAGRF WQVCEKHKVN
360 370 380 390 400
VFYTAPTAIR ALMSIGDDLV NQADLSSLRL LGTVGEPINP EAWHWYYEVV
410 420 430 440 450
GKSNCPIVDT WWQTETGGIL ITSLPGAVDM KPGCAGKPFF GVQPALFDKD
460 470 480 490 500
GNTLEGENAG LLVMTASWPG QLRTVYGDHN RFYQTYLGQY PGNYFTGDGA
510 520 530 540 550
KRDEDGYYWI TGRVDDVLNV SGHRLGTAEI ESALVLHPAV AEAAVVGYPH
560 570 580 590 600
EIKGQGVYCY VTLMGNATES DELNVELREF VAKELGRFAK PDYIQWSPGL
610 620 630 640
PKTRSGKIMR RILRKIAEND VDSLGDTSTL ADPSVVENLI DKRIIHGA
Length:648
Mass (Da):71,614
Last modified:September 13, 2005 - v1
Checksum:i12B79CF080B776AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ26507.1
RefSeqiWP_011044699.1, NC_003910.7

Genome annotation databases

EnsemblBacteriaiAAZ26507; AAZ26507; CPS_3955
KEGGicps:CPS_3955

Similar proteinsi

Entry informationi

Entry nameiQ47X57_COLP3
AccessioniPrimary (citable) accession number: Q47X57
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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