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Q47X57

- Q47X57_COLP3

UniProt

Q47X57 - Q47X57_COLP3

Protein

Acetyl-coenzyme A synthetase

Gene

acs

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei309 – 3091Coenzyme AUniRule annotation
    Binding sitei385 – 3851Substrate; via nitrogen amideUniRule annotation
    Binding sitei498 – 4981SubstrateUniRule annotation
    Binding sitei513 – 5131SubstrateUniRule annotation
    Active sitei515 – 5151UniRule annotation
    Binding sitei521 – 5211Coenzyme AUniRule annotation
    Binding sitei524 – 5241SubstrateUniRule annotation
    Metal bindingi535 – 5351Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi537 – 5371Magnesium; via carbonyl oxygenUniRule annotation
    Metal bindingi540 – 5401Magnesium; via carbonyl oxygenUniRule annotation
    Binding sitei582 – 5821Coenzyme AUniRule annotation

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
    2. AMP binding Source: InterPro
    3. ATP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from acetate Source: InterPro

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-3955-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
    Short name:
    AcCoA synthetaseUniRule annotation
    Short name:
    AcsUniRule annotation
    Alternative name(s):
    Acetate--CoA ligaseUniRule annotation
    Acyl-activating enzymeUniRule annotation
    Gene namesi
    Name:acsImported
    Synonyms:acsAUniRule annotation
    Ordered Locus Names:CPS_3955Imported
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)Imported
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei607 – 6071N6-acetyllysineUniRule annotation

    Post-translational modificationi

    Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

    Keywords - PTMi

    AcetylationUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi167879.CPS_3955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47X57.
    SMRiQ47X57. Positions 20-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni409 – 4146Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0365.
    HOGENOMiHOG000229981.
    KOiK01895.
    OMAiHPPQKML.
    OrthoDBiEOG68WR2H.

    Family and domain databases

    HAMAPiMF_01123. Ac_CoA_synth.
    InterProiIPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q47X57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKELKSCYPV SEKAKAHTHI DAATYDAMYK KSIEQPDEFW GEQAKEFIDW    50
    YKPWDSVSKV DLKNSEINWF SGGKLNVSYN CIDRHLATKA NDTAIIFEGD 100
    DPNDDSKVTY QELHDHVCRF ANLLKERGVK KGDRVCIYMP MIPEVGYAML 150
    ACARIGAIHS VVFGGFSTES IKARVLDADC KVVITADQSL RGGKRIPLKS 200
    NVDAAVIDCP NVHSVIVVAR TGGDVAWNDK VDINYEEAVA KQSAICEPEV 250
    MDAEDPLFVL YTSGSTGTPK GVVHTCGGYI LYAAMTHKYV FDYKEGEVYW 300
    CTADAGWITG HSYIFYGPLA NGATTLVFEG VPTYPDAGRF WQVCEKHKVN 350
    VFYTAPTAIR ALMSIGDDLV NQADLSSLRL LGTVGEPINP EAWHWYYEVV 400
    GKSNCPIVDT WWQTETGGIL ITSLPGAVDM KPGCAGKPFF GVQPALFDKD 450
    GNTLEGENAG LLVMTASWPG QLRTVYGDHN RFYQTYLGQY PGNYFTGDGA 500
    KRDEDGYYWI TGRVDDVLNV SGHRLGTAEI ESALVLHPAV AEAAVVGYPH 550
    EIKGQGVYCY VTLMGNATES DELNVELREF VAKELGRFAK PDYIQWSPGL 600
    PKTRSGKIMR RILRKIAEND VDSLGDTSTL ADPSVVENLI DKRIIHGA 648
    Length:648
    Mass (Da):71,614
    Last modified:September 13, 2005 - v1
    Checksum:i12B79CF080B776AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26507.1.
    RefSeqiWP_011044699.1. NC_003910.7.
    YP_270613.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ26507; AAZ26507; CPS_3955.
    GeneIDi3520759.
    KEGGicps:CPS_3955.
    PATRICi21470797. VBIColPsy94388_3583.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26507.1 .
    RefSeqi WP_011044699.1. NC_003910.7.
    YP_270613.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q47X57.
    SMRi Q47X57. Positions 20-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_3955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ26507 ; AAZ26507 ; CPS_3955 .
    GeneIDi 3520759.
    KEGGi cps:CPS_3955.
    PATRICi 21470797. VBIColPsy94388_3583.

    Phylogenomic databases

    eggNOGi COG0365.
    HOGENOMi HOG000229981.
    KOi K01895.
    OMAi HPPQKML.
    OrthoDBi EOG68WR2H.

    Enzyme and pathway databases

    BioCyci CPSY167879:GI48-3955-MONOMER.

    Family and domain databases

    HAMAPi MF_01123. Ac_CoA_synth.
    InterProi IPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681Imported.

    Entry informationi

    Entry nameiQ47X57_COLP3
    AccessioniPrimary (citable) accession number: Q47X57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3