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Q47X57

- Q47X57_COLP3

UniProt

Q47X57 - Q47X57_COLP3

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Protein
Acetyl-coenzyme A synthetase
Gene
acs, acsA, CPS_3955
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Coenzyme A By similarityUniRule annotation
Binding sitei385 – 3851Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei498 – 4981Substrate By similarityUniRule annotation
Binding sitei513 – 5131Substrate By similarityUniRule annotation
Active sitei515 – 5151 By similarityUniRule annotation
Binding sitei521 – 5211Coenzyme A By similarityUniRule annotation
Binding sitei524 – 5241Substrate By similarityUniRule annotation
Metal bindingi535 – 5351Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi537 – 5371Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi540 – 5401Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei582 – 5821Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:GI48-3955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsImported
Synonyms:acsAUniRule annotation
Ordered Locus Names:CPS_3955Imported
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)Imported
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei607 – 6071N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_3955.

Structurei

3D structure databases

ProteinModelPortaliQ47X57.
SMRiQ47X57. Positions 20-643.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni409 – 4146Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiHPPQKML.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47X57-1 [UniParc]FASTAAdd to Basket

« Hide

MKELKSCYPV SEKAKAHTHI DAATYDAMYK KSIEQPDEFW GEQAKEFIDW    50
YKPWDSVSKV DLKNSEINWF SGGKLNVSYN CIDRHLATKA NDTAIIFEGD 100
DPNDDSKVTY QELHDHVCRF ANLLKERGVK KGDRVCIYMP MIPEVGYAML 150
ACARIGAIHS VVFGGFSTES IKARVLDADC KVVITADQSL RGGKRIPLKS 200
NVDAAVIDCP NVHSVIVVAR TGGDVAWNDK VDINYEEAVA KQSAICEPEV 250
MDAEDPLFVL YTSGSTGTPK GVVHTCGGYI LYAAMTHKYV FDYKEGEVYW 300
CTADAGWITG HSYIFYGPLA NGATTLVFEG VPTYPDAGRF WQVCEKHKVN 350
VFYTAPTAIR ALMSIGDDLV NQADLSSLRL LGTVGEPINP EAWHWYYEVV 400
GKSNCPIVDT WWQTETGGIL ITSLPGAVDM KPGCAGKPFF GVQPALFDKD 450
GNTLEGENAG LLVMTASWPG QLRTVYGDHN RFYQTYLGQY PGNYFTGDGA 500
KRDEDGYYWI TGRVDDVLNV SGHRLGTAEI ESALVLHPAV AEAAVVGYPH 550
EIKGQGVYCY VTLMGNATES DELNVELREF VAKELGRFAK PDYIQWSPGL 600
PKTRSGKIMR RILRKIAEND VDSLGDTSTL ADPSVVENLI DKRIIHGA 648
Length:648
Mass (Da):71,614
Last modified:September 13, 2005 - v1
Checksum:i12B79CF080B776AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26507.1.
RefSeqiWP_011044699.1. NC_003910.7.
YP_270613.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ26507; AAZ26507; CPS_3955.
GeneIDi3520759.
KEGGicps:CPS_3955.
PATRICi21470797. VBIColPsy94388_3583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26507.1 .
RefSeqi WP_011044699.1. NC_003910.7.
YP_270613.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47X57.
SMRi Q47X57. Positions 20-643.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167879.CPS_3955.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ26507 ; AAZ26507 ; CPS_3955 .
GeneIDi 3520759.
KEGGi cps:CPS_3955.
PATRICi 21470797. VBIColPsy94388_3583.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi HPPQKML.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci CPSY167879:GI48-3955-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiQ47X57_COLP3
AccessioniPrimary (citable) accession number: Q47X57
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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