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Q47WJ3

- CPDA_COLP3

UniProt

Q47WJ3 - CPDA_COLP3

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211Metal cation 1UniRule annotation
    Metal bindingi23 – 231Metal cation 1UniRule annotation
    Binding sitei23 – 231cAMPUniRule annotation
    Metal bindingi62 – 621Metal cation 1UniRule annotation
    Metal bindingi62 – 621Metal cation 2UniRule annotation
    Binding sitei62 – 621cAMPUniRule annotation
    Metal bindingi94 – 941Metal cation 2UniRule annotation
    Metal bindingi160 – 1601Metal cation 2UniRule annotation
    Metal bindingi198 – 1981Metal cation 2UniRule annotation
    Metal bindingi200 – 2001Metal cation 1UniRule annotation
    Binding sitei200 – 2001cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi94 – 952cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-4179-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Synonyms:icc
    Ordered Locus Names:CPS_4178
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2632633',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413365Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167879.CPS_4178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47WJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    KOiK03651.
    OMAiWQIIMLD.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q47WJ3-1 [UniParc]FASTAAdd to Basket

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    MTITEPYSPN NQPITFAQIT DSHLFSSVDG LHHGHNVLAN LKKVLLSICD    50
    NPSIKYIIFT GDLTQDHTEQ SYQNFVDCVL ECHITVPIYY LAGNHDEPKL 100
    LDKYFSASPF QADKEINLSH WQVQLVDSKS ATPAGYVGEQ ALVKLKDAIQ 150
    KNKNQLLMMH HHPIDVGYFI DKHGLQNKDA FWQVINSYDN IKAIACGHVH 200
    GDMTLTNAIT SPINEPVVLY TCPATSIQFD PTVDGVAALS KGPGYRLFSL 250
    YADGQLNTEV VML 263
    Length:263
    Mass (Da):29,285
    Last modified:September 13, 2005 - v1
    Checksum:iA1CD6A3C86FEF5FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26872.1.
    RefSeqiWP_011044910.1. NC_003910.7.
    YP_270829.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ26872; AAZ26872; CPS_4178.
    GeneIDi3521127.
    KEGGicps:CPS_4178.
    PATRICi21471219. VBIColPsy94388_3791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26872.1 .
    RefSeqi WP_011044910.1. NC_003910.7.
    YP_270829.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q47WJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_4178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ26872 ; AAZ26872 ; CPS_4178 .
    GeneIDi 3521127.
    KEGGi cps:CPS_4178.
    PATRICi 21471219. VBIColPsy94388_3791.

    Phylogenomic databases

    eggNOGi COG1409.
    KOi K03651.
    OMAi WQIIMLD.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci CPSY167879:GI48-4179-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681.

    Entry informationi

    Entry nameiCPDA_COLP3
    AccessioniPrimary (citable) accession number: Q47WJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3