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Q47WJ3 (CPDA_COLP3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Synonyms:icc
Ordered Locus Names:CPS_4178
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2632633',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413365

Regions

Nucleotide binding94 – 952cAMP By similarity

Sites

Metal binding211Metal cation 1 By similarity
Metal binding231Metal cation 1 By similarity
Metal binding621Metal cation 1 By similarity
Metal binding621Metal cation 2 By similarity
Metal binding941Metal cation 2 By similarity
Metal binding1601Metal cation 2 By similarity
Metal binding1981Metal cation 2 By similarity
Metal binding2001Metal cation 1 By similarity
Binding site231cAMP By similarity
Binding site621cAMP By similarity
Binding site2001cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47WJ3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: A1CD6A3C86FEF5FB

FASTA26329,285
        10         20         30         40         50         60 
MTITEPYSPN NQPITFAQIT DSHLFSSVDG LHHGHNVLAN LKKVLLSICD NPSIKYIIFT 

        70         80         90        100        110        120 
GDLTQDHTEQ SYQNFVDCVL ECHITVPIYY LAGNHDEPKL LDKYFSASPF QADKEINLSH 

       130        140        150        160        170        180 
WQVQLVDSKS ATPAGYVGEQ ALVKLKDAIQ KNKNQLLMMH HHPIDVGYFI DKHGLQNKDA 

       190        200        210        220        230        240 
FWQVINSYDN IKAIACGHVH GDMTLTNAIT SPINEPVVLY TCPATSIQFD PTVDGVAALS 

       250        260 
KGPGYRLFSL YADGQLNTEV VML 

« Hide

References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000083 Genomic DNA. Translation: AAZ26872.1.
RefSeqYP_270829.1. NC_003910.7.

3D structure databases

ProteinModelPortalQ47WJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167879.CPS_4178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ26872; AAZ26872; CPS_4178.
GeneID3521127.
KEGGcps:CPS_4178.
PATRIC21471219. VBIColPsy94388_3791.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1409.
KOK03651.
OMAWQIIMLD.
OrthoDBEOG6QG8GQ.

Enzyme and pathway databases

BioCycCPSY167879:GI48-4179-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_COLP3
AccessionPrimary (citable) accession number: Q47WJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families