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Q47WJ3

- CPDA_COLP3

UniProt

Q47WJ3 - CPDA_COLP3

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1UniRule annotation
Metal bindingi23 – 231Metal cation 1UniRule annotation
Binding sitei23 – 231cAMPUniRule annotation
Metal bindingi62 – 621Metal cation 1UniRule annotation
Metal bindingi62 – 621Metal cation 2UniRule annotation
Binding sitei62 – 621cAMPUniRule annotation
Metal bindingi94 – 941Metal cation 2UniRule annotation
Metal bindingi160 – 1601Metal cation 2UniRule annotation
Metal bindingi198 – 1981Metal cation 2UniRule annotation
Metal bindingi200 – 2001Metal cation 1UniRule annotation
Binding sitei200 – 2001cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi94 – 952cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:GI48-4179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:icc
Ordered Locus Names:CPS_4178
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2632633',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413365Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_4178.

Structurei

3D structure databases

ProteinModelPortaliQ47WJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47WJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTITEPYSPN NQPITFAQIT DSHLFSSVDG LHHGHNVLAN LKKVLLSICD
60 70 80 90 100
NPSIKYIIFT GDLTQDHTEQ SYQNFVDCVL ECHITVPIYY LAGNHDEPKL
110 120 130 140 150
LDKYFSASPF QADKEINLSH WQVQLVDSKS ATPAGYVGEQ ALVKLKDAIQ
160 170 180 190 200
KNKNQLLMMH HHPIDVGYFI DKHGLQNKDA FWQVINSYDN IKAIACGHVH
210 220 230 240 250
GDMTLTNAIT SPINEPVVLY TCPATSIQFD PTVDGVAALS KGPGYRLFSL
260
YADGQLNTEV VML
Length:263
Mass (Da):29,285
Last modified:September 13, 2005 - v1
Checksum:iA1CD6A3C86FEF5FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ26872.1.
RefSeqiYP_270829.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ26872; AAZ26872; CPS_4178.
GeneIDi3521127.
KEGGicps:CPS_4178.
PATRICi21471219. VBIColPsy94388_3791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ26872.1 .
RefSeqi YP_270829.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47WJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_4178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ26872 ; AAZ26872 ; CPS_4178 .
GeneIDi 3521127.
KEGGi cps:CPS_4178.
PATRICi 21471219. VBIColPsy94388_3791.

Phylogenomic databases

eggNOGi COG1409.
KOi K03651.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CPSY167879:GI48-4179-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiCPDA_COLP3
AccessioniPrimary (citable) accession number: Q47WJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3