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Q47WJ3

- CPDA_COLP3

UniProt

Q47WJ3 - CPDA_COLP3

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, icc, CPS_4178
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Metal cation 1 By similarity
Metal bindingi23 – 231Metal cation 1 By similarity
Binding sitei23 – 231cAMP By similarity
Metal bindingi62 – 621Metal cation 1 By similarity
Metal bindingi62 – 621Metal cation 2 By similarity
Binding sitei62 – 621cAMP By similarity
Metal bindingi94 – 941Metal cation 2 By similarity
Metal bindingi160 – 1601Metal cation 2 By similarity
Metal bindingi198 – 1981Metal cation 2 By similarity
Metal bindingi200 – 2001Metal cation 1 By similarity
Binding sitei200 – 2001cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi94 – 952cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:GI48-4179-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Synonyms:icc
Ordered Locus Names:CPS_4178
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2632633',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413365Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_4178.

Structurei

3D structure databases

ProteinModelPortaliQ47WJ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47WJ3-1 [UniParc]FASTAAdd to Basket

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MTITEPYSPN NQPITFAQIT DSHLFSSVDG LHHGHNVLAN LKKVLLSICD    50
NPSIKYIIFT GDLTQDHTEQ SYQNFVDCVL ECHITVPIYY LAGNHDEPKL 100
LDKYFSASPF QADKEINLSH WQVQLVDSKS ATPAGYVGEQ ALVKLKDAIQ 150
KNKNQLLMMH HHPIDVGYFI DKHGLQNKDA FWQVINSYDN IKAIACGHVH 200
GDMTLTNAIT SPINEPVVLY TCPATSIQFD PTVDGVAALS KGPGYRLFSL 250
YADGQLNTEV VML 263
Length:263
Mass (Da):29,285
Last modified:September 13, 2005 - v1
Checksum:iA1CD6A3C86FEF5FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26872.1.
RefSeqiWP_011044910.1. NC_003910.7.
YP_270829.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ26872; AAZ26872; CPS_4178.
GeneIDi3521127.
KEGGicps:CPS_4178.
PATRICi21471219. VBIColPsy94388_3791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26872.1 .
RefSeqi WP_011044910.1. NC_003910.7.
YP_270829.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47WJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_4178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ26872 ; AAZ26872 ; CPS_4178 .
GeneIDi 3521127.
KEGGi cps:CPS_4178.
PATRICi 21471219. VBIColPsy94388_3791.

Phylogenomic databases

eggNOGi COG1409.
KOi K03651.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CPSY167879:GI48-4179-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiCPDA_COLP3
AccessioniPrimary (citable) accession number: Q47WJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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