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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21Metal cation 1UniRule annotation1
Metal bindingi23Metal cation 1UniRule annotation1
Binding sitei23cAMPUniRule annotation1
Metal bindingi62Metal cation 1UniRule annotation1
Metal bindingi62Metal cation 2UniRule annotation1
Binding sitei62cAMPUniRule annotation1
Metal bindingi94Metal cation 2UniRule annotation1
Metal bindingi160Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 2UniRule annotation1
Metal bindingi200Metal cation 1UniRule annotation1
Binding sitei200cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi94 – 95cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:G1G4N-3815-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:icc
Ordered Locus Names:CPS_4178
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133651 – 2633',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST263

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_4178

Structurei

3D structure databases

ProteinModelPortaliQ47WJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
KOiK03651
OMAiCAWLDQH
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

Q47WJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITEPYSPN NQPITFAQIT DSHLFSSVDG LHHGHNVLAN LKKVLLSICD
60 70 80 90 100
NPSIKYIIFT GDLTQDHTEQ SYQNFVDCVL ECHITVPIYY LAGNHDEPKL
110 120 130 140 150
LDKYFSASPF QADKEINLSH WQVQLVDSKS ATPAGYVGEQ ALVKLKDAIQ
160 170 180 190 200
KNKNQLLMMH HHPIDVGYFI DKHGLQNKDA FWQVINSYDN IKAIACGHVH
210 220 230 240 250
GDMTLTNAIT SPINEPVVLY TCPATSIQFD PTVDGVAALS KGPGYRLFSL
260
YADGQLNTEV VML
Length:263
Mass (Da):29,285
Last modified:September 13, 2005 - v1
Checksum:iA1CD6A3C86FEF5FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ26872.1
RefSeqiWP_011044910.1, NC_003910.7

Genome annotation databases

EnsemblBacteriaiAAZ26872; AAZ26872; CPS_4178
KEGGicps:CPS_4178

Similar proteinsi

Entry informationi

Entry nameiCPDA_COLP3
AccessioniPrimary (citable) accession number: Q47WJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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