Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q47W82 (Q47W82_COLP3) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384
Ordered Locus Names:CPS_4290
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP] EMBL AAZ26876.1
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm By similarity HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis HAMAP MF_00384
   Cellular componentCytoplasm HAMAP MF_00384
   LigandATP-binding HAMAP MF_00384
Nucleotide-binding
   Molecular functionKinase HAMAP MF_00384 EMBL AAZ26876.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding107 – 11711ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
Q47W82 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 3180DFB6DA638E4D

FASTA32835,254
        10         20         30         40         50         60 
MSVSNTNVNK SVSVFAPASI GNVSVGFDVL GLAVKPVDGT LLGDVVTVNA TTSNDNSLTV 

        70         80         90        100        110        120 
IGNFADKLPS NKEDNIVWSC LLLFNEQLIS VKQTPVFVAI TLDKKMPVGS GLGSSACSVV 

       130        140        150        160        170        180 
AALASLNAFY AKYHNFSFSE NVVLKMTGQM EAQISGSLHY DNVAPCYLGG LQLMVPDENV 

       190        200        210        220        230        240 
ISRILPSFDD CYYVMAYPGI EVSTKAAREV LPTTYSRSDV ISYGQNLATF VDACHRQDKS 

       250        260        270        280        290        300 
QAFSVLTDVI AEPYRTDLLP KYKASRDYLS SQGALAVGIS GSGPTLFCVC DSEKQAEQFA 

       310        320 
LWLQENYLQT ALGFVHVCKV DDVGATEI

« Hide

References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000083 Genomic DNA. Translation: AAZ26876.1.
RefSeqYP_270940.1. NC_003910.7.

3D structure databases

ProteinModelPortalQ47W82.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ47W82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3521131.
GenomeReviewsGene locus CPS_4290 in contig CP000083_GR.
KEGGcps:CPS_4290.
NMPDRfig|167879.3.peg.4480.
PATRIC21471439. VBIColPsy94388_3901.
TIGRCPS_4290.

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHBG646290.
OMAGSAHADN.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ47W82_COLP3
AccessionPrimary (citable) accession number: Q47W82
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info