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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Manganese 2UniRule annotation1
Active sitei63Phosphoserine intermediateUniRule annotation1
Metal bindingi63Manganese 2UniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei342SubstrateUniRule annotation1
Metal bindingi409Manganese 1UniRule annotation1
Metal bindingi413Manganese 1UniRule annotation1
Metal bindingi450Manganese 2UniRule annotation1
Metal bindingi451Manganese 2UniRule annotation1
Metal bindingi469Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Synonyms:gpmA
Ordered Locus Names:CPS_4391
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002121391 – 5202,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST520

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_4391

Structurei

3D structure databases

ProteinModelPortaliQ47VY2
SMRiQ47VY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingUniRule annotation2
Regioni268 – 271Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJI Bacteria
COG0696 LUCA
HOGENOMiHOG000223664
KOiK15633
OMAiFMDGRDT
OrthoDBiPOG091H01EL

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.101 hit
3.40.720.102 hits
HAMAPiMF_01038 GpmI, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

Q47VY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKKSTVLM ILDGWGYREE TSSNAIHQAN TPVLDNLKAK YPNMLIDTSG
60 70 80 90 100
MAVGLPEGQM GNSEVGHVNL GAGRVVYQDF TRITKAISDG DFIENPTLCH
110 120 130 140 150
AVDTATSNNK AVHIFGLLSP GGVHSHEEHI FAMMELAKKR GAQKVYLHAF
160 170 180 190 200
LDGRDTPPRS AQASLEKAQQ KFSKLFTETD TGEGQIASVI GRYYAMDRDQ
210 220 230 240 250
RWDRVEAAYN LMVNGEGLHQ YNSALDALAA AYERNENDEF VGASAITSPS
260 270 280 290 300
GKAIKVNDGD ALIFMNFRAD RARQFSRCFT DTNFNGFERK RIPAISNFVM
310 320 330 340 350
LTQYAADIDA PSAFAPTPLT NVMGEWLAKH NKTQLRISET EKYAHVTFFF
360 370 380 390 400
SGGKEDMFTG EERILVPSPD VATYDLQPEM NSTLLTDKLV GAIESGKYDF
410 420 430 440 450
IVCNYPNGDM VGHTGSFDAA VKACEAVDTC VGRVVKAAQD NGGECLITAD
460 470 480 490 500
HGNAEQMQDP VSGQAHTAHT CEPVPLIYVG RNASPAASGT LSDISPSVLH
510 520
LMGMEQPQEM TGSVLMQLIK
Length:520
Mass (Da):56,657
Last modified:September 13, 2005 - v1
Checksum:i206391609EA74823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA Translation: AAZ25836.1

Genome annotation databases

EnsemblBacteriaiAAZ25836; AAZ25836; CPS_4391
KEGGicps:CPS_4391

Similar proteinsi

Entry informationi

Entry nameiGPMI_COLP3
AccessioniPrimary (citable) accession number: Q47VY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome