Q47VS4 (COAE_COLP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	CPS_4450

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity HAMAP MF_00376.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dephospho-CoA kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000243277
Regions
	Domain	5 – 202	198	DPCK
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q47VS4 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 54698B3F2768CF1F	FASTA	202	22,260
	10 20 30 40 50 60 MSKLVIGLTG GIGSGKTTIT NYFLALGVEI IDADIIAREV VAINSPALKA IAKHFGDDYI 70 80 90 100 110 120 QADGQLNRPL LRNRIFSNKA DKLWLNKLLH PLIRVNIVTQ TKEAKSPYCI LVAPLLIENN 130 140 150 160 170 180 LLELVDRVLI VDVNESTQIT RTLVRDSSSE QEIKAIIASQ TSRAARVNVA DDIINNDDSP 190 200 LSEIKEAVLS LDKKYLTLTK MV

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000083 Genomic DNA. Translation: AAZ26036.1.
RefSeq	YP_271098.1. NC_003910.7.
3D structure databases
ProteinModelPortal	Q47VS4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47VS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3520284.
GenomeReviews	Gene locus CPS_4450 in contig CP000083_GR.
KEGG	cps:CPS_4450.
NMPDR	fig|167879.3.peg.4166.
PATRIC	21471737. VBIColPsy94388_4049.
TIGR	CPS_4450.
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HBG650290.
OMA	YVIMVVP.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_4450-MONOMER.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
KO	K00859.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_COLP3

Accession

Primary (citable) accession number: Q47VS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program