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Q47VM6

- GCH4_COLP3

UniProt

Q47VM6 - GCH4_COLP3

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei155 – 1551May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-4499-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:CPS_4498
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GTP cyclohydrolase FolE2PRO_0000289486Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167879.CPS_4498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47VM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q47VM6-1 [UniParc]FASTAAdd to Basket

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    MTTSMPDIAN HTTAQTEGTL DWVGMSNIEM PIMVASKGES ERMVSAHIDA    50
    FVNLKDAQAK GIHMSRLYLL IDELSTSNIL NYQSLVSLLD GFISSHQELS 100
    DQAKVQFCFD YHLRRKSLIS GKEGWKAYPV TLTGNLNQGK LTIELTIDVP 150
    YSSTCPCSAA LARQLIQKAF QDKFAQQSEL ALTDVHDWLG TTEGIVATPH 200
    SQRSVAEVKV KLNSSINDFP ITEIVDLVEN SLKTPVQAAV KREDEQEFAR 250
    LNGQNLMFCE DAARRLQHSL NQTDQFDDFW LRINHLESLH AHDAVSVTTK 300
    GIKDGYQP 308
    Length:308
    Mass (Da):34,396
    Last modified:September 13, 2005 - v1
    Checksum:i3FC1F4D96981A399
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ28290.1.
    RefSeqiYP_271146.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ28290; AAZ28290; CPS_4498.
    GeneIDi3522549.
    KEGGicps:CPS_4498.
    PATRICi21471821. VBIColPsy94388_4091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ28290.1 .
    RefSeqi YP_271146.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q47VM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_4498.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ28290 ; AAZ28290 ; CPS_4498 .
    GeneIDi 3522549.
    KEGGi cps:CPS_4498.
    PATRICi 21471821. VBIColPsy94388_4091.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CPSY167879:GI48-4499-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681.

    Entry informationi

    Entry nameiGCH4_COLP3
    AccessioniPrimary (citable) accession number: Q47VM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3