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Q47VJ9

- PDXA_COLP3

UniProt

Q47VJ9 - PDXA_COLP3

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, CPS_4525
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Metal bindingi164 – 1641Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi209 – 2091Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi264 – 2641Divalent metal cation; shared with dimeric partner By similarity
Binding sitei272 – 2721Substrate By similarity
Binding sitei281 – 2811Substrate By similarity
Binding sitei290 – 2901Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciCPSY167879:GI48-4526-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:CPS_4525
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3263264-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000128239Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_4525.

Structurei

3D structure databases

ProteinModelPortaliQ47VJ9.
SMRiQ47VJ9. Positions 2-325.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47VJ9-1 [UniParc]FASTAAdd to Basket

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MTQRIAITPG EPAGVGPDLI ITIAQQDWPV EMVVIASKAL LQERSKALSL    50
PLTIIDYDQH APAKSQKSGS LTVLDVELTE PCVPGTLNSA NGSYVVETLR 100
IASEKNISGE FDAIVTGPVH KGLINKAGIA FSGHTEYFAT QANCSDVVMM 150
LATKGLRVAL VTTHIPLAYV SKAITYERLQ KVTRILHKDL QEKFGIKSPK 200
IYACGINPHA GEDGHLGREE IEIMEPAFAE LRADGIDIIG PLPADTIFQE 250
KYLAEADAIL AMYHDQGLPV LKYKGFGSSV NITLGLPFIR TSVDHGTALE 300
LAGKGTADSG SFIEAMNNAI NLASNK 326
Length:326
Mass (Da):34,947
Last modified:September 13, 2005 - v1
Checksum:iC7BD6E284AC6B7DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ28186.1.
RefSeqiYP_271173.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ28186; AAZ28186; CPS_4525.
GeneIDi3522445.
KEGGicps:CPS_4525.
PATRICi21471875. VBIColPsy94388_4118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ28186.1 .
RefSeqi YP_271173.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q47VJ9.
SMRi Q47VJ9. Positions 2-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_4525.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ28186 ; AAZ28186 ; CPS_4525 .
GeneIDi 3522445.
KEGGi cps:CPS_4525.
PATRICi 21471875. VBIColPsy94388_4118.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci CPSY167879:GI48-4526-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiPDXA_COLP3
AccessioniPrimary (citable) accession number: Q47VJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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