ID   APAH_COLP3              Reviewed;         285 AA.
AC   Q47VJ7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=CPS_4527;
OS   Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS   psychroerythus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Colwellia.
OX   NCBI_TaxID=167879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA   Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA   Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA   Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA   Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA   Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT   "The psychrophilic lifestyle as revealed by the genome sequence of
RT   Colwellia psychrerythraea 34H through genomic and proteomic
RT   analyses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000083; AAZ27360.1; -; Genomic_DNA.
DR   RefSeq; YP_271175.1; -.
DR   GeneID; 3521618; -.
DR   GenomeReviews; CP000083_GR; CPS_4527.
DR   KEGG; cps:CPS_4527; -.
DR   NMPDR; fig|167879.3.peg.4322; -.
DR   TIGR; CPS_4527; -.
DR   HOGENOM; Q47VJ7; -.
DR   OMA; Q47VJ7; LVFGHWA.
DR   BioCyc; CPSY167879:CPS_4527-MON; -.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    285       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012055.
SQ   SEQUENCE   285 AA;  32144 MW;  DC2E406FF46BC861 CRC64;
     MAIYLVGDIQ GCFNELSSLL LQVNFDRNND VLYLAGDLVA RGPNSLETLR FVKSLGESAK
     VVLGNHDLHL LSVHAGIKKA KKSDNLSALL AAPDVNELMD WLAAQPLLQE IPNTCSNSNA
     INQANNNSAY MSHAGISPQW QLSVALEQAK FIQTKLASSD RNTWLALMYG EKPNDWHQAI
     TEIERFRYSI NAFTRMRFCF TDGTLEFEQK DSPENITLTN IVPWYELSQT INNTSWVFGH
     WASLMGKSSH PNIYPLDTGC VWGNQLTMLR WHDKKYFIQS SELSD
//