Reviewed, UniProtKB/Swiss-Prot Q47VJ7 (APAH_COLP3)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	CPS_4527

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012055

Sequences

	Sequence		Length	Mass (Da)
	Q47VJ7-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: DC2E406FF46BC861	FASTA	285	32,144
	10 20 30 40 50 60 MAIYLVGDIQ GCFNELSSLL LQVNFDRNND VLYLAGDLVA RGPNSLETLR FVKSLGESAK 70 80 90 100 110 120 VVLGNHDLHL LSVHAGIKKA KKSDNLSALL AAPDVNELMD WLAAQPLLQE IPNTCSNSNA 130 140 150 160 170 180 INQANNNSAY MSHAGISPQW QLSVALEQAK FIQTKLASSD RNTWLALMYG EKPNDWHQAI 190 200 210 220 230 240 TEIERFRYSI NAFTRMRFCF TDGTLEFEQK DSPENITLTN IVPWYELSQT INNTSWVFGH 250 260 270 280 WASLMGKSSH PNIYPLDTGC VWGNQLTMLR WHDKKYFIQS SELSD

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ27360.1.
RefSeq	YP_271175.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3521618.
GenomeReviews	Gene locus CPS_4527 in contig CP000083_GR.
KEGG	cps:CPS_4527.
NMPDR	fig|167879.3.peg.4322.
TIGR	CPS_4527.
Phylogenomic databases
HOGENOM	Q47VJ7.
OMA	Q47VJ7. LVFGHWA.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_4527-MON.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_COLP3

Accession

Primary (citable) accession number: Q47VJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)