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Q47UP4 (ILVC_COLP3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:CPS_4839
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190936

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
Q47UP4 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 5D915C3D30AA194A

FASTA49354,220
        10         20         30         40         50         60 
MSNYFNTLSL REKLGQLGKC RFMKREEFND GCNFIKDWNI VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LNISYTLRDA AISEKRQSWQ WATENGFTVG SYAELIPQAD LVLNLTPDKQ HTSAVTAVMP 

       130        140        150        160        170        180 
LMKQGATLAY SHGFNIVEEG MQIRSDITVV MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPQGNGLAI AKAYASATGG DRAGVLESSF IAEVKSDLMG EQTILCGMLQ TAAVLGHKQL 

       250        260        270        280        290        300 
IAQGMDAAYA RKLLQYGLET TTEGLKHGGI TNMMDRLSNP AKILAFDMAE ELKVILRPLF 

       310        320        330        340        350        360 
QKHMDDIIEG RFSATMMADW ANDDVNLLTW RAETAETSFE KSPECDTEIS EQEYYDKGIF 

       370        380        390        400        410        420 
VVAMIKAGVE LAFDAMVDSG IINASAYYES LHETPLIANC IARNMLHEMN VVISDTAEYG 

       430        440        450        460        470        480 
NYLFTHAAVP LLADYTASLT LEQLGEGLKE SSNNVDNARL IEVNEAIRSH GVEVIGKELR 

       490 
GYMTDMKKIA SAK

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References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000083 Genomic DNA. Translation: AAZ28265.1.
RefSeqYP_271478.1. NC_003910.7.

3D structure databases

HSSPHSSP built from PDB template 1YRL based on UniProtKB P05793.
ProteinModelPortalQ47UP4.
SMRQ47UP4. Positions 3-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ47UP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3522524.
GenomeReviewsGene locus CPS_4839 in contig CP000083_GR.
KEGGcps:CPS_4839.
NMPDRfig|167879.3.peg.4696.
PATRIC21472491. VBIColPsy94388_4418.
TIGRCPS_4839.

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycCPSY167879:CPS_4839-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_COLP3
AccessionPrimary (citable) accession number: Q47UP4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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