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Q47RU5

- PNP_THEFY

UniProt

Q47RU5 - PNP_THEFY

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Tfu_0784
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi509 – 5091Magnesium By similarity
Metal bindingi515 – 5151Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Tfu_0784
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329910Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_0784.

Structurei

3D structure databases

ProteinModelPortaliQ47RU5.
SMRiQ47RU5. Positions 5-712.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini575 – 63460KHAdd
BLAST
Domaini646 – 71873S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47RU5-1 [UniParc]FASTAAdd to Basket

« Hide

MEGVYSAEAV IDNGRFGTRT IRFETGRLAR QATGSATAYL DDETMVLSAT    50
TVSKRPKEAL DFFPLTVDVE ERMYAAGRIP GSFFRREGRP SEDAILTCRL 100
IDRPLRPSFQ KGLRNEIQIV ATVLALHPDH LYDVIAINAA SMSTQLAGLP 150
FSGPIGGVRV ALVEGQWVAF PTHSELANAT FDMVVAGRVL DNGDVAIMMV 200
EAESTPHTLR LVAEGAIGPN EQTVAEGLEA AKPFIKVLCR AQQTVAEAAG 250
KPPGEYPIFI DYQDDAYAAV EEAIHDELAA ALTIADKQER EAELDRVKAL 300
VAEKLAEDFE GREKELAAAF RALTRKLVRE RIVKDGVRID GRGVKDIRSL 350
TAEVNVIPRV HGSALFERGE TQILGITTLN MLRMEQTIDT LNPERTKRYM 400
HNYNFPPYST GETGRVGAPK RREIGHGALA ERALVPVLPS REEFPYAIRQ 450
VSEAIGSNGS TSMGSVCAST MSLMAAGVPL KDMVAGIAMG LIYEDGKYVT 500
LTDILGAEDA YGDMDFKVAG TRDLITALQL DTKLDGIPAE VLASALQQAR 550
GARLAILDVM SEAINRPAEI SPHAPRILTV KVPIDKIGEV IGPKGKMINS 600
IQDETGAEIT IEDDGTIYIG ATDGPSAEAA RDAINSIANP TMPEVGERYL 650
GTVVKTTAFG AFVSLLPGKD GLLHISQIRK MHGGQRIENV EDVISIGEKI 700
HVEVRDIDER GKLSLVPVEV IEAEAVAAPN GGESPNGAKK TDASGNGAKQ 750
PRRRRRTRSS SRSSENT 767
Length:767
Mass (Da):82,792
Last modified:September 13, 2005 - v1
Checksum:i5079ACAA0DEBDEC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ54822.1.
RefSeqiYP_288845.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ54822; AAZ54822; Tfu_0784.
GeneIDi3581349.
KEGGitfu:Tfu_0784.
PATRICi23902026. VBITheFus33945_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ54822.1 .
RefSeqi YP_288845.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47RU5.
SMRi Q47RU5. Positions 5-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_0784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ54822 ; AAZ54822 ; Tfu_0784 .
GeneIDi 3581349.
KEGGi tfu:Tfu_0784.
PATRICi 23902026. VBITheFus33945_0815.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TFUS269800:GI42-800-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiPNP_THEFY
AccessioniPrimary (citable) accession number: Q47RU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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