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Q47RU5

- PNP_THEFY

UniProt

Q47RU5 - PNP_THEFY

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi509 – 5091MagnesiumUniRule annotation
Metal bindingi515 – 5151MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Tfu_0784
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Polyribonucleotide nucleotidyltransferasePRO_0000329910Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_0784.

Structurei

3D structure databases

ProteinModelPortaliQ47RU5.
SMRiQ47RU5. Positions 5-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini575 – 63460KHUniRule annotationAdd
BLAST
Domaini646 – 71873S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47RU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGVYSAEAV IDNGRFGTRT IRFETGRLAR QATGSATAYL DDETMVLSAT
60 70 80 90 100
TVSKRPKEAL DFFPLTVDVE ERMYAAGRIP GSFFRREGRP SEDAILTCRL
110 120 130 140 150
IDRPLRPSFQ KGLRNEIQIV ATVLALHPDH LYDVIAINAA SMSTQLAGLP
160 170 180 190 200
FSGPIGGVRV ALVEGQWVAF PTHSELANAT FDMVVAGRVL DNGDVAIMMV
210 220 230 240 250
EAESTPHTLR LVAEGAIGPN EQTVAEGLEA AKPFIKVLCR AQQTVAEAAG
260 270 280 290 300
KPPGEYPIFI DYQDDAYAAV EEAIHDELAA ALTIADKQER EAELDRVKAL
310 320 330 340 350
VAEKLAEDFE GREKELAAAF RALTRKLVRE RIVKDGVRID GRGVKDIRSL
360 370 380 390 400
TAEVNVIPRV HGSALFERGE TQILGITTLN MLRMEQTIDT LNPERTKRYM
410 420 430 440 450
HNYNFPPYST GETGRVGAPK RREIGHGALA ERALVPVLPS REEFPYAIRQ
460 470 480 490 500
VSEAIGSNGS TSMGSVCAST MSLMAAGVPL KDMVAGIAMG LIYEDGKYVT
510 520 530 540 550
LTDILGAEDA YGDMDFKVAG TRDLITALQL DTKLDGIPAE VLASALQQAR
560 570 580 590 600
GARLAILDVM SEAINRPAEI SPHAPRILTV KVPIDKIGEV IGPKGKMINS
610 620 630 640 650
IQDETGAEIT IEDDGTIYIG ATDGPSAEAA RDAINSIANP TMPEVGERYL
660 670 680 690 700
GTVVKTTAFG AFVSLLPGKD GLLHISQIRK MHGGQRIENV EDVISIGEKI
710 720 730 740 750
HVEVRDIDER GKLSLVPVEV IEAEAVAAPN GGESPNGAKK TDASGNGAKQ
760
PRRRRRTRSS SRSSENT
Length:767
Mass (Da):82,792
Last modified:September 13, 2005 - v1
Checksum:i5079ACAA0DEBDEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ54822.1.
RefSeqiWP_011291231.1. NC_007333.1.
YP_288845.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ54822; AAZ54822; Tfu_0784.
GeneIDi3581349.
KEGGitfu:Tfu_0784.
PATRICi23902026. VBITheFus33945_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ54822.1 .
RefSeqi WP_011291231.1. NC_007333.1.
YP_288845.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47RU5.
SMRi Q47RU5. Positions 5-712.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_0784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ54822 ; AAZ54822 ; Tfu_0784 .
GeneIDi 3581349.
KEGGi tfu:Tfu_0784.
PATRICi 23902026. VBITheFus33945_0815.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TFUS269800:GI42-800-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiPNP_THEFY
AccessioniPrimary (citable) accession number: Q47RU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3