Q47R29 (Q47R29_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

Tfu_1050

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q47R29 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 037D9262A967C2D5	FASTA	312	34,617
	10 20 30 40 50 60 MLGSPTPRPA PRPRRISELL ARKEPTFSFE FFPPKTPEGE RMLWRAIREI EALRPSFVSV 70 80 90 100 110 120 TYGAGGSTRD RTVNVTEKIA TNTTLLPVAH ITAVNHSVRE LRHLIGRFAA AGVCNMLALR 130 140 150 160 170 180 GDPPGDPLGE WVKHPEGLTH AEELVRLIKE SGDFCVGVAA FPYKHPRSPD VETDTDFFVR 190 200 210 220 230 240 KCRAGADYAI TQMFFEAEDY LRLRDRVAAR GCDVPIIPEI MPVTKFSTIA RSEQLSGAPF 250 260 270 280 290 300 PRRLAEEFER VADDPEAVRA LGIEHATRLC ERLLAEGAPG IHFITFNRST ATREVYHRLV 310 GATQPAAVAA LP

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ55088.1.
RefSeq	YP_289111.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47R29.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47R29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3579602.
GenomeReviews	Gene locus Tfu_1050 in contig CP000088_GR.
KEGG	tfu:Tfu_1050.
NMPDR	fig|269800.4.peg.1258.
PATRIC	23902588. VBITheFus33945_1094.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q47R29.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_1050-MONOMER.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q47R29_THEFY

Accession

Primary (citable) accession number: Q47R29

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)