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Q47R24 (Q47R24_THEFY) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:Tfu_1055
OrganismThermobifida fusca (strain YX) [Complete proteome] [HAMAP]
Taxonomic identifier269800 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
Q47R24 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: CF6634E851441CC2

FASTA43145,712
        10         20         30         40         50         60 
MTTTTRYLIR NARILGGEPT DLLLAHGRID AIGPDLPADG AEVVDAAGAI ALPGLVDLHT 

        70         80         90        100        110        120 
HLREPGREDA ETVATGSRAA AMGGYTAVFA MANTDPVADT AGVVEQVWRL GRDAGYCDVH 

       130        140        150        160        170        180 
PVGAVTVGLK GERLAELGAM ADSPAKVRVF SDDGMCVSDA QLMRRALEYV KAFDGVIAQH 

       190        200        210        220        230        240 
AQEPRLTEGA QMNEGVVSDR LGLAGWPAVA EEAIIARDCL LAEHVGSRLH VCHVSTKGSV 

       250        260        270        280        290        300 
QIIRWAKSRG CDVTAEVTPH HLLLTDELAE SYDPVYKVNP PLRTAEDVEA LREGLADGTI 

       310        320        330        340        350        360 
DIVATDHAPH PSEAKETEWN QAAMGMIGLE TALSVVQHTM VDTGLLDWAG VAQRMSATPA 

       370        380        390        400        410        420 
RIGRLTDQGR PIAVGEPANL TLYDPTATRV IDPATMVSKS RNTPFAGMTL PGRVLATFLR 

       430 
GVPTVLDGKI Q

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References

[1]"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX."
Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N.
J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000088 Genomic DNA. Translation: AAZ55093.1.
RefSeqYP_289116.1. NC_007333.1.

3D structure databases

ProteinModelPortalQ47R24.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ47R24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3579607.
GenomeReviewsGene locus Tfu_1055 in contig CP000088_GR.
KEGGtfu:Tfu_1055.
NMPDRfig|269800.4.peg.1263.
PATRIC23902600. VBITheFus33945_1100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
HOGENOMHBG724623.
OMACDVHPVG.
PhylomeDBQ47R24.
ProtClustDBPRK09357.

Enzyme and pathway databases

BioCycTFUS269800:TFU_1055-MONOMER.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ47R24_THEFY
AccessionPrimary (citable) accession number: Q47R24
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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