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Q47R19

- PYRF_THEFY

UniProt

Q47R19 - PYRF_THEFY

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, Tfu_1060
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Substrate By similarity
Binding sitei32 – 321Substrate By similarity
Active sitei62 – 621Proton donor By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei176 – 1761Substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei205 – 2051Substrate; via amide nitrogen By similarity
Binding sitei206 – 2061Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1078-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Tfu_1060
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000241924Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_1060.

Structurei

3D structure databases

ProteinModelPortaliQ47R19.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 6910Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiIGMELLM.
OrthoDBiEOG6WQD34.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47R19-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPIAVALD APDVETASRW AAAVAPHVST LKVGLELYLR YGPAVVEAVR    50
GARETALFLD LKLHDIPATV AGAARSVAGL APAFLTVHAA GGADMVRAAV 100
EAAPETRIAA VTVLTSLDEA ALGAVGMRGP ARDAVRRLAV LAVEAGARAL 150
VCSPQEAAMV RAEVGPDVTL ITPGVRPAGA AQGDQARVAT PEAALAAGAD 200
LLVIGRPITR APDPGAAAAA LAAELQKTGA SPS 233
Length:233
Mass (Da):23,157
Last modified:September 13, 2005 - v1
Checksum:i22F30A76CB1FC2F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55098.1.
RefSeqiWP_011291507.1. NC_007333.1.
YP_289121.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ55098; AAZ55098; Tfu_1060.
GeneIDi3580052.
KEGGitfu:Tfu_1060.
PATRICi23902610. VBITheFus33945_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55098.1 .
RefSeqi WP_011291507.1. NC_007333.1.
YP_289121.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47R19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_1060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ55098 ; AAZ55098 ; Tfu_1060 .
GeneIDi 3580052.
KEGGi tfu:Tfu_1060.
PATRICi 23902610. VBITheFus33945_1105.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi IGMELLM.
OrthoDBi EOG6WQD34.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci TFUS269800:GI42-1078-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiPYRF_THEFY
AccessioniPrimary (citable) accession number: Q47R19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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