Q47QX7 (RSMH_THEFY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase H
EC=2.1.1.199

Alternative name(s):
16S rRNA m(4)C1402 methyltransferase
rRNA (cytosine-N(4)-)-methyltransferase RsmH

Gene names

Name:	rsmH
Synonyms:	mraW
Ordered Locus Names:	Tfu_1102

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA By similarity. HAMAP MF_01007
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. HAMAP MF_01007
Subcellular location	Cytoplasm By similarity HAMAP MF_01007.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Ribosomal RNA small subunit methyltransferase H HAMAP MF_01007		PRO_0000223570
Regions
	Region	51 – 53	3	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	70	1	S-adenosyl-L-methionine By similarity
	Binding site	118	1	S-adenosyl-L-methionine By similarity
	Binding site	125	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47QX7 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 86C310E0C47DB720	FASTA	330	35,955
	10 20 30 40 50 60 MTGDAPQSAP QHRGSPAPAH VPVMLERVVE LLAPALQQPG AIAVDGTLGL GGHAEALLRA 70 80 90 100 110 120 HPGLRLVGVD RDTTALERAR QRLAPYADRI DLVHAVYSDI PRILDELGID RVHGLLFDLG 130 140 150 160 170 180 VSSPQLDEAE RGFAYSYDAP LDMRMDRTQE RTAADIVNTY PASELTRIFR VYGEERFAAR 190 200 210 220 230 240 IAQAIVRQRA KEPVRTTGVL ADLVRSAIPA AARRSGGHPA KRAFQALRIE VNSELSILER 250 260 270 280 290 300 ALPAALSRLA VAGRIVVLSY HSLEDRITKR VLTELSTDST PPGLPVPLPD RQPELRLLTR 310 320 330 GAELPTEQET AANPRAASAR LRAAERTREP

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YX.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ55140.1.
RefSeq	YP_289163.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47QX7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47QX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3579284.
GenomeReviews	Gene locus Tfu_1102 in contig CP000088_GR.
KEGG	tfu:Tfu_1102.
NMPDR	fig|269800.4.peg.350.
PATRIC	23902698. VBITheFus33945_1149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0275.
HOGENOM	HBG302779.
OMA	NPATRAF.
PhylomeDB	Q47QX7.
ProtClustDB	CLSK2769169.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_1102-MONOMER.
Family and domain databases
HAMAP	MF_01007. 16SrRNA_methyltr_H. [Tree]
InterPro	IPR002903. SAM-dep_MeTrfase_MraW. IPR023397. SAM-dep_MeTrfase_MraW_recog. [Graphical view]
Gene3D	G3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
KO	K03438.
PANTHER	PTHR11265. Bact_methyltrans. 1 hit.
Pfam	PF01795. Methyltransf_5. 1 hit. [Graphical view]
PIRSF	PIRSF004486. MraW. 1 hit.
SUPFAM	SSF81799. SSF81799. 1 hit.
TIGRFAMs	TIGR00006. TIGR00006. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RSMH_THEFY

Accession

Primary (citable) accession number: Q47QX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program