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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Thermobifida fusca (strain YX)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51MagnesiumCombined sources1
Binding sitei136GTPUniRule annotation1
Binding sitei140GTPUniRule annotation1
Binding sitei184GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 22GTPUniRule annotation5
Nucleotide bindingi105 – 107GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:G1G4Q-1133-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Tfu_1113Imported
OrganismiThermobifida fusca (strain YX)Imported
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_1113

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E6EX-ray2.12A1-313[»]
ProteinModelPortaliQ47QW6
SMRiQ47QW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 202TubulinInterPro annotationAdd BLAST193
Domaini204 – 321Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG091H02KK

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q47QW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQNYLAV IKVVGIGGGG VNAVNRMIEE GLKGVEFIAI NTDAQALLMS
60 70 80 90 100
DADVKLDVGR ELTRGLGAGA NPDVGRKAAE DHREEIEEVL KGADMVFVTA
110 120 130 140 150
GEGGGTGTGG APVVANIARS LGALTIGVVT RPFSFEGKRR ATQAEAGIAM
160 170 180 190 200
LREEVDTLIV IPNDRLLSIS DRQVSVLDAF KAADQVLLSG VQGITDLITT
210 220 230 240 250
PGLINLDFAD VKSVMSGAGS ALMGIGSARG DDRAVAAAEM AISSPLLEAS
260 270 280 290 300
IDGAHGVLLS IQGGSDLGLF EINEAAQLVA NSAAAEANII FGAVIDDALG
310 320 330 340 350
DEVRVTVIAA GFDEPQVESP SPTPSRAVSA PTTPAAPERF TPPPPPPPPL
360 370 380 390 400
RTVEPPRSEP PTPSLARDPR PTTEPDSGAE TAAEPAATEE PQSDSAAASE
410 420 430 440 450
AKETKDTPAN RDEDRPYRPG GLYPMGGEGG YTRPRVSDSP FSRSGEIPTP
460
RRRVVFDEGD DLDVPDFLK
Length:469
Mass (Da):48,518
Last modified:September 13, 2005 - v1
Checksum:i19E2C52BA30DB2ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA Translation: AAZ55151.1
RefSeqiWP_011291560.1, NC_007333.1

Genome annotation databases

EnsemblBacteriaiAAZ55151; AAZ55151; Tfu_1113
KEGGitfu:Tfu_1113

Similar proteinsi

Entry informationi

Entry nameiQ47QW6_THEFY
AccessioniPrimary (citable) accession number: Q47QW6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health