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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Thermobifida fusca (strain YX)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361GTPUniRule annotation
Binding sitei140 – 1401GTPUniRule annotation
Binding sitei184 – 1841GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 225GTPUniRule annotation
Nucleotide bindingi105 – 1073GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Tfu_1113Imported
OrganismiThermobifida fusca (strain YX)Imported
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_1113.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E6EX-ray2.12A1-313[»]
ProteinModelPortaliQ47QW6.
SMRiQ47QW6. Positions 22-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 202193TubulinInterPro annotationAdd
BLAST
Domaini204 – 321118Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiNNAREEL.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47QW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQNYLAV IKVVGIGGGG VNAVNRMIEE GLKGVEFIAI NTDAQALLMS
60 70 80 90 100
DADVKLDVGR ELTRGLGAGA NPDVGRKAAE DHREEIEEVL KGADMVFVTA
110 120 130 140 150
GEGGGTGTGG APVVANIARS LGALTIGVVT RPFSFEGKRR ATQAEAGIAM
160 170 180 190 200
LREEVDTLIV IPNDRLLSIS DRQVSVLDAF KAADQVLLSG VQGITDLITT
210 220 230 240 250
PGLINLDFAD VKSVMSGAGS ALMGIGSARG DDRAVAAAEM AISSPLLEAS
260 270 280 290 300
IDGAHGVLLS IQGGSDLGLF EINEAAQLVA NSAAAEANII FGAVIDDALG
310 320 330 340 350
DEVRVTVIAA GFDEPQVESP SPTPSRAVSA PTTPAAPERF TPPPPPPPPL
360 370 380 390 400
RTVEPPRSEP PTPSLARDPR PTTEPDSGAE TAAEPAATEE PQSDSAAASE
410 420 430 440 450
AKETKDTPAN RDEDRPYRPG GLYPMGGEGG YTRPRVSDSP FSRSGEIPTP
460
RRRVVFDEGD DLDVPDFLK
Length:469
Mass (Da):48,518
Last modified:September 13, 2005 - v1
Checksum:i19E2C52BA30DB2ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ55151.1.
RefSeqiWP_011291560.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ55151; AAZ55151; Tfu_1113.
KEGGitfu:Tfu_1113.
PATRICi23902722. VBITheFus33945_1161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ55151.1.
RefSeqiWP_011291560.1. NC_007333.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E6EX-ray2.12A1-313[»]
ProteinModelPortaliQ47QW6.
SMRiQ47QW6. Positions 22-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_1113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ55151; AAZ55151; Tfu_1113.
KEGGitfu:Tfu_1113.
PATRICi23902722. VBITheFus33945_1161.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiNNAREEL.
OrthoDBiEOG6S7XZG.

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1131-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YXImported.
  2. "Crystal structure of a putative cell division protein FtsZ (Tfu_1113) from Thermobifida fusca YX-ER1 at 2.22 A resolution (PSI Community Target, van Wezel G.P.)."
    Joint Center for Structural Genomics (JCSG)
    Submitted (MAR-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 1-313.

Entry informationi

Entry nameiQ47QW6_THEFY
AccessioniPrimary (citable) accession number: Q47QW6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.