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Q47QS9

- HISX_THEFY

UniProt

Q47QS9 - HISX_THEFY

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Protein
Histidinol dehydrogenase
Gene
hisD, Tfu_1150
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei193 – 1931NAD By similarity
Binding sitei216 – 2161NAD By similarity
Binding sitei239 – 2391Substrate By similarity
Metal bindingi261 – 2611Zinc By similarity
Binding sitei261 – 2611Substrate By similarity
Metal bindingi264 – 2641Zinc By similarity
Binding sitei264 – 2641Substrate By similarity
Active sitei330 – 3301Proton acceptor By similarity
Active sitei331 – 3311Proton acceptor By similarity
Binding sitei331 – 3311Substrate By similarity
Metal bindingi364 – 3641Zinc By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei418 – 4181Substrate By similarity
Metal bindingi423 – 4231Zinc By similarity
Binding sitei423 – 4231Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1168-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Tfu_1150
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenaseUniRule annotation
PRO_0000135868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_1150.

Structurei

3D structure databases

ProteinModelPortaliQ47QS9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47QS9-1 [UniParc]FASTAAdd to Basket

« Hide

MRSVISRIDL RGNPADPRAS LPRAEIDVAS AVEKVRPICE DVRHRGVEAL    50
IELGERFDGV RPAHIRVPAD ALETALAGLD RTVRAALEEA IRRARIVHRD 100
QRRTDTTTRV VPGGTVTERW VPVDRVGLYV PGGRAVYPSS VVMNVVPAQE 150
AGVPSLAVAS PPQAEFGGLP HPTILAACAL LGVDEVYAVG GAQAIAMFAY 200
GAGECAPVSM VTGPGNIWVA AAKRLLKGII GIDSEAGPTE IAILADDTAN 250
PAYVAADLIS QAEHDVVAAS VLVTPSTALA DRVEAELARQ VPAAKHRERI 300
TQALGGPQSG IVLVDDIDHG LDVVNAYAPE HLEVMTADAQ SVAARVRNAG 350
AIFIGDHSPV SLGDYCAGSN HVLPTGGVAV HSSGLSVQSF LRGIHVVEYD 400
RAALAEVAHH VVALAEAEDL PAHGAAVTAR IPREEQQA 438
Length:438
Mass (Da):45,811
Last modified:September 13, 2005 - v1
Checksum:iC6657EAC246CA868
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55188.1.
RefSeqiYP_289211.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ55188; AAZ55188; Tfu_1150.
GeneIDi3581196.
KEGGitfu:Tfu_1150.
PATRICi23902804. VBITheFus33945_1202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55188.1 .
RefSeqi YP_289211.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47QS9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_1150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ55188 ; AAZ55188 ; Tfu_1150 .
GeneIDi 3581196.
KEGGi tfu:Tfu_1150.
PATRICi 23902804. VBITheFus33945_1202.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TFUS269800:GI42-1168-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiHISX_THEFY
AccessioniPrimary (citable) accession number: Q47QS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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