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Q47NZ5

- PSA_THEFY

UniProt

Q47NZ5 - PSA_THEFY

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Protein

Proteasome subunit alpha

Gene

prcA

Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1793-MONOMER.
UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PrcAUniRule annotation
Gene namesi
Name:prcAUniRule annotation
Ordered Locus Names:Tfu_1789
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Proteasome subunit alphaPRO_0000397180Add
BLAST

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_1789.

Structurei

3D structure databases

ProteinModelPortaliQ47NZ5.
SMRiQ47NZ5. Positions 8-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000245319.
KOiK03432.
OMAiGRYNEFE.
OrthoDBiEOG6NKQZG.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47NZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMPFYVSPE QIMKDKADYA RKGIARGRSA VVLQYEGGIL FVADNVSRTL
60 70 80 90 100
HKISELYDRV AFAAVGRYNE FENLRLAGVR FADMHGYTYD RSDVTGQMLA
110 120 130 140 150
NAYAQTLGAV FTESSKPWEV EIVVAEVGDS PDSDQIYRIT FDGSVVDERD
160 170 180 190 200
FLAMGGSAER VTAALRERYV KNMSLTDALR VAVHGLAHEN GERRELKASS
210 220 230 240
LEVAMLERSR PHRKFRRIQG ERLARMLQEA REAEEAAEAQ SSEDGGATD
Length:249
Mass (Da):27,824
Last modified:September 13, 2005 - v1
Checksum:i0C8A282E40B6D122
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55824.1.
RefSeqiYP_289847.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ55824; AAZ55824; Tfu_1789.
GeneIDi3580469.
KEGGitfu:Tfu_1789.
PATRICi23904188. VBITheFus33945_1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55824.1 .
RefSeqi YP_289847.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47NZ5.
SMRi Q47NZ5. Positions 8-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_1789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ55824 ; AAZ55824 ; Tfu_1789 .
GeneIDi 3580469.
KEGGi tfu:Tfu_1789.
PATRICi 23904188. VBITheFus33945_1926.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000245319.
KOi K03432.
OMAi GRYNEFE.
OrthoDBi EOG6NKQZG.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci TFUS269800:GI42-1793-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00289_B. Proteasome_A_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03691. 20S_bact_alpha. 1 hit.
PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiPSA_THEFY
AccessioniPrimary (citable) accession number: Q47NZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3