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Q47NK1

- DUT_THEFY

UniProt

Q47NK1 - DUT_THEFY

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, Tfu_1935
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate By similarity
Binding sitei117 – 1171Substrate; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-1939-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:Tfu_1935
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000231432Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_1935.

Structurei

3D structure databases

ProteinModelPortaliQ47NK1.
SMRiQ47NK1. Positions 28-165.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni90 – 923Substrate binding By similarity
Regioni107 – 1093Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028966.
KOiK01520.
OMAiFERFDRI.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47NK1-1 [UniParc]FASTAAdd to Basket

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MGALRDVGRP PNAIGSAVVS DLSPVFGTVR VEIRRLDPDL PLPRYAHPGD    50
AGADLVTAED VVLAPGERAT VRTGIAIALP DGYAAFIHPR SGLAARHGLT 100
VVNAPGTVDA GYRGEIKVPL LNTDPATPVK LTRGDRIAQL VIQRVERAAF 150
VEVDELSDSA RGAGGFGSTG GHAAGAEQS 179
Length:179
Mass (Da):18,444
Last modified:September 13, 2005 - v1
Checksum:iD7CDCE5D1CEFFB99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55968.1.
RefSeqiYP_289991.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ55968; AAZ55968; Tfu_1935.
GeneIDi3580613.
KEGGitfu:Tfu_1935.
PATRICi23904488. VBITheFus33945_2078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ55968.1 .
RefSeqi YP_289991.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47NK1.
SMRi Q47NK1. Positions 28-165.
ModBasei Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_1935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ55968 ; AAZ55968 ; Tfu_1935 .
GeneIDi 3580613.
KEGGi tfu:Tfu_1935.
PATRICi 23904488. VBITheFus33945_2078.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028966.
KOi K01520.
OMAi FERFDRI.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci TFUS269800:GI42-1939-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiDUT_THEFY
AccessioniPrimary (citable) accession number: Q47NK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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