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Q47NA3

- NADK_THEFY

UniProt

Q47NA3 - NADK_THEFY

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Protein

NAD kinase

Gene
nadK, Tfu_2033
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton acceptor By similarity
Binding sitei98 – 981NAD By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei201 – 2011NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 942NAD By similarity
Nucleotide bindingi171 – 1722NAD By similarity
Nucleotide bindingi212 – 2176NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Tfu_2033
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326NAD kinaseUniRule annotationPRO_0000229705Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_2033.

Structurei

3D structure databases

ProteinModelPortaliQ47NA3.
SMRiQ47NA3. Positions 20-317.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47NA3-1 [UniParc]FASTAAdd to Basket

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MKTSESTDRF GGVAGETTNR TVLLLAHTGR PAALRSARLV HESLTRAGVT    50
VRMLASEIEA IRKTGARMQP VEVVEPGADA AAGTELIMVL GGDGTLLRAA 100
ELARPAGAPL LGVNLGHVGF LAEAERDDLS DTVRCVVERD YSVEERMTID 150
VAVYNGGRTS AAPAVRTWAL NEATAEKVES GRMLEVVLEI DGRPLSRWGC 200
DGVVCATPTG STAHAFSGGG PIVWPSVEAL LVVPLSAHAL FARPLVVAPD 250
AVIALEVLPE TTDGVLWCDG RRRVELPAGA RVEISRSKTP VRLARLQQAP 300
FTNRLVAKFA LPVAGWRGRA AERDSG 326
Length:326
Mass (Da):34,490
Last modified:September 13, 2005 - v1
Checksum:i822833BDC2A12C1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56066.1.
RefSeqiWP_011292456.1. NC_007333.1.
YP_290089.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56066; AAZ56066; Tfu_2033.
GeneIDi3580790.
KEGGitfu:Tfu_2033.
PATRICi23904706. VBITheFus33945_2189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56066.1 .
RefSeqi WP_011292456.1. NC_007333.1.
YP_290089.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47NA3.
SMRi Q47NA3. Positions 20-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_2033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ56066 ; AAZ56066 ; Tfu_2033 .
GeneIDi 3580790.
KEGGi tfu:Tfu_2033.
PATRICi 23904706. VBITheFus33945_2189.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci TFUS269800:GI42-2038-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiNADK_THEFY
AccessioniPrimary (citable) accession number: Q47NA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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