ID   Q47N62_THEFY            Unreviewed;       617 AA.
AC   Q47N62;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   SubName: Full=Tyrosine protein kinase:Serine/threonine protein kinase {ECO:0000313|EMBL:AAZ56107.1};
GN   OrderedLocusNames=Tfu_2074 {ECO:0000313|EMBL:AAZ56107.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Nocardiopsaceae; Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ56107.1};
RN   [1] {ECO:0000313|EMBL:AAZ56107.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YX {ECO:0000313|EMBL:AAZ56107.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA   Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of Thermobifida fusca YX.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000088; AAZ56107.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q47N62; -.
DR   STRING; 269800.Tfu_2074; -.
DR   KEGG; tfu:Tfu_2074; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_513711_0_0_11; -.
DR   OrthoDB; 3415202at2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR43671:SF13; LD04361P; 1.
DR   PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:AAZ56107.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:AAZ56107.1};
KW   Transferase {ECO:0000313|EMBL:AAZ56107.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..277
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          343..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   617 AA;  63789 MW;  E81E34BA5CC7A594 CRC64;
     MSRRSERTIS VLVPPDLAPT APEDPRTIGP YVLVGRLGAT ETGSVYAAVH PDVEPEALLA
     VKVIPSSRVA DEAARTRLEQ RLRTLGAVDG RCYVPPVAFD VHGTPPWLAT RYSPGTPLKQ
     YIDQRGPLRL GRLTALAAGL GEALSALHSL DVVHGDLKPS SVLLSSAGPR LLDCALSGEA
     PAPAGSTPWL SPERLRGEAP TPASDVFSWG AVLAFAATGK PPFGTGTPEE VAERIASGSP
     DLSDAAEEIR SLLESALAAD PAERPNIREL VRSSISLWES SLGTVGSEAG PGSGVTRVLT
     REWQGIVEPA LLPRVVHLDD RARGKKSGLR SLTMPVPLLS RSTAQPASSA AAADAPDSTG
     PTSSGAAATA VTAQEDTEAN TDTPAKAASA PSSSSSAPAA PPASSPSTGP SGSKGPNKRF
     LALVGGGAAA ALLLLGGGVW AVSALRGDDP EPQDVTAQPD SAPEEAPQEE PPPAWDTGTL
     VVRLDSSSDV HLLAGPWPYT PVKPASGDDA FAGLNGREVT PEEWSEAWAP VPGVEEPLEA
     LIASDAEVMC AHFCLNPDQV YVDEEGRGTY KVTGRDLGNY LSWGDAVIAE VTFGEPDPET
     GLPVITKVTE LYPLPTA
//