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Q47N41

- RUVC_THEFY

UniProt

Q47N41 - RUVC_THEFY

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71MagnesiumUniRule annotation
    Metal bindingi68 – 681MagnesiumUniRule annotation
    Metal bindingi141 – 1411MagnesiumUniRule annotation
    Metal bindingi144 – 1441MagnesiumUniRule annotation

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciTFUS269800:GI42-2103-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
    Alternative name(s):
    Holliday junction nuclease RuvCUniRule annotation
    Holliday junction resolvase RuvCUniRule annotation
    Gene namesi
    Name:ruvCUniRule annotation
    Ordered Locus Names:Tfu_2095
    OrganismiThermobifida fusca (strain YX)
    Taxonomic identifieri269800 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
    ProteomesiUP000000434: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Crossover junction endodeoxyribonuclease RuvCPRO_0000225182Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269800.Tfu_2095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47N41.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012182.
    KOiK01159.
    OMAiCHAWRGG.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.
    PROSITEiPS01321. RUVC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q47N41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLGIDPGL TRCGIGVVDG AVGAPLTMVA AGAVRTLADE ELPARLLGIE    50
    KGIEQWLDDY QPDAVAVERV FAQHNVRTVM GTAQASAIAV VCAARRGLPV 100
    SLHTPSEVKA AITGSGRADK AQVGTMVARI LRLDSPPRPA DAADAVALAI 150
    CYLWRGSAQE RIARARQKFA RTIELARQRH GL 182
    Length:182
    Mass (Da):19,280
    Last modified:September 13, 2005 - v1
    Checksum:iFF743576BCCEF57F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000088 Genomic DNA. Translation: AAZ56128.1.
    RefSeqiYP_290151.1. NC_007333.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ56128; AAZ56128; Tfu_2095.
    GeneIDi3579355.
    KEGGitfu:Tfu_2095.
    PATRICi23904838. VBITheFus33945_2252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000088 Genomic DNA. Translation: AAZ56128.1 .
    RefSeqi YP_290151.1. NC_007333.1.

    3D structure databases

    ProteinModelPortali Q47N41.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269800.Tfu_2095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ56128 ; AAZ56128 ; Tfu_2095 .
    GeneIDi 3579355.
    KEGGi tfu:Tfu_2095.
    PATRICi 23904838. VBITheFus33945_2252.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012182.
    KOi K01159.
    OMAi CHAWRGG.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci TFUS269800:GI42-2103-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    PROSITEi PS01321. RUVC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YX.

    Entry informationi

    Entry nameiRUVC_THEFY
    AccessioniPrimary (citable) accession number: Q47N41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3