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Q47MY0

- SYL_THEFY

UniProt

Q47MY0 - SYL_THEFY

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Protein
Leucine--tRNA ligase
Gene
leuS, Tfu_2156
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei596 – 5961ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Tfu_2156
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Leucine--tRNA ligaseUniRule annotation
PRO_0000334834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_2156.

Structurei

3D structure databases

ProteinModelPortaliQ47MY0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionUniRule annotation
Add
BLAST
Motifi593 – 5975"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEICAPEQ.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47MY0-1 [UniParc]FASTAAdd to Basket

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MTAVSGDQTT SGSYDVRALQ EKWQARWAKE NPFTASEDPA DPRPRRYVLD    50
MFPYPSGDLH MGHAEAFAIG DVIARYHFAR GENVLHPIGW DSFGLPAENA 100
AIKHNFHPAE WTYTNIETQA ESFRRYAISL DWSRRLHTSD PEYYRWNQWF 150
FLRFFERGLA YRKDGLVNWC PKDQTVLANE QVIQGKCERC GTEVERRALN 200
QWYFKITDYA QRLLDDMEQL EGKWPERVLT MQRNWIGRSE GADVQFTIEG 250
REEPVTVFTT RPDTLYGATF FVVAPDSPLA DELCAPEQRE AFEAYRTQVS 300
KLSDIERQST EREKTGVFLG RYAINPVNGE RIPVWAADYV LADYGHGAIM 350
AVPAHDQRDL DFARKFNLPV RVVVDTGEPD PAETGIATPG EGTLINSGPL 400
NGLSKSEAIP RIIEILTERG TGKAAVNYRL RDWLVSRQRF WGTPIPIIHC 450
PECGEVPVPD EELPVRLPDL RGAALAPKGV SPLAAATDWV NVSCPRCGGP 500
AKRDTDTMDT FVDSSWYFLR YCSPNLDTAP FDQEKVAKWG PIDQYVGGVE 550
HAILHLLYSR FFTKVLYDMG MVPFTEPFVR LLNQGQVINQ GKAMSKSLGN 600
GVDLGQEIDR YGVDAVRLTM VFAGPPEEDI DWADVSPGAS VKFLNRAYRV 650
MAEAAAASAP GVDPATGDLA LRRMTHQTLA KVTEAVEAQR FNVAIARIME 700
LVTAARRAID SGPGAADPAV REAAEVIAIT LGLFAPYVAE EGWEMLGHTG 750
SVSVGTWREP DPALLVQESV TCVVQVASKV RDKLQVSPDI SAEELERLAL 800
ASEKVQNHIA GREIRRIVVR EPKLVNIVVA 830
Length:830
Mass (Da):92,640
Last modified:September 13, 2005 - v1
Checksum:i1A44B3A2BAE1EACE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56189.1.
RefSeqiWP_011292579.1. NC_007333.1.
YP_290212.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56189; AAZ56189; Tfu_2156.
GeneIDi3581446.
KEGGitfu:Tfu_2156.
PATRICi23904974. VBITheFus33945_2313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56189.1 .
RefSeqi WP_011292579.1. NC_007333.1.
YP_290212.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47MY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_2156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ56189 ; AAZ56189 ; Tfu_2156 .
GeneIDi 3581446.
KEGGi tfu:Tfu_2156.
PATRICi 23904974. VBITheFus33945_2313.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi EICAPEQ.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TFUS269800:GI42-2171-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiSYL_THEFY
AccessioniPrimary (citable) accession number: Q47MY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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