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Q47MY0

- SYL_THEFY

UniProt

Q47MY0 - SYL_THEFY

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei596 – 5961ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2171-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tfu_2156
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Leucine--tRNA ligasePRO_0000334834Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269800.Tfu_2156.

Structurei

3D structure databases

ProteinModelPortaliQ47MY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionAdd
BLAST
Motifi593 – 5975"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEICAPEQ.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47MY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAVSGDQTT SGSYDVRALQ EKWQARWAKE NPFTASEDPA DPRPRRYVLD
60 70 80 90 100
MFPYPSGDLH MGHAEAFAIG DVIARYHFAR GENVLHPIGW DSFGLPAENA
110 120 130 140 150
AIKHNFHPAE WTYTNIETQA ESFRRYAISL DWSRRLHTSD PEYYRWNQWF
160 170 180 190 200
FLRFFERGLA YRKDGLVNWC PKDQTVLANE QVIQGKCERC GTEVERRALN
210 220 230 240 250
QWYFKITDYA QRLLDDMEQL EGKWPERVLT MQRNWIGRSE GADVQFTIEG
260 270 280 290 300
REEPVTVFTT RPDTLYGATF FVVAPDSPLA DELCAPEQRE AFEAYRTQVS
310 320 330 340 350
KLSDIERQST EREKTGVFLG RYAINPVNGE RIPVWAADYV LADYGHGAIM
360 370 380 390 400
AVPAHDQRDL DFARKFNLPV RVVVDTGEPD PAETGIATPG EGTLINSGPL
410 420 430 440 450
NGLSKSEAIP RIIEILTERG TGKAAVNYRL RDWLVSRQRF WGTPIPIIHC
460 470 480 490 500
PECGEVPVPD EELPVRLPDL RGAALAPKGV SPLAAATDWV NVSCPRCGGP
510 520 530 540 550
AKRDTDTMDT FVDSSWYFLR YCSPNLDTAP FDQEKVAKWG PIDQYVGGVE
560 570 580 590 600
HAILHLLYSR FFTKVLYDMG MVPFTEPFVR LLNQGQVINQ GKAMSKSLGN
610 620 630 640 650
GVDLGQEIDR YGVDAVRLTM VFAGPPEEDI DWADVSPGAS VKFLNRAYRV
660 670 680 690 700
MAEAAAASAP GVDPATGDLA LRRMTHQTLA KVTEAVEAQR FNVAIARIME
710 720 730 740 750
LVTAARRAID SGPGAADPAV REAAEVIAIT LGLFAPYVAE EGWEMLGHTG
760 770 780 790 800
SVSVGTWREP DPALLVQESV TCVVQVASKV RDKLQVSPDI SAEELERLAL
810 820 830
ASEKVQNHIA GREIRRIVVR EPKLVNIVVA
Length:830
Mass (Da):92,640
Last modified:September 13, 2005 - v1
Checksum:i1A44B3A2BAE1EACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56189.1.
RefSeqiYP_290212.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56189; AAZ56189; Tfu_2156.
GeneIDi3581446.
KEGGitfu:Tfu_2156.
PATRICi23904974. VBITheFus33945_2313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56189.1 .
RefSeqi YP_290212.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47MY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_2156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ56189 ; AAZ56189 ; Tfu_2156 .
GeneIDi 3581446.
KEGGi tfu:Tfu_2156.
PATRICi 23904974. VBITheFus33945_2313.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi EICAPEQ.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TFUS269800:GI42-2171-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiSYL_THEFY
AccessioniPrimary (citable) accession number: Q47MY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3