Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q47MY0

- SYL_THEFY

UniProt

Q47MY0 - SYL_THEFY

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei596 – 5961ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTFUS269800:GI42-2171-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tfu_2156
    OrganismiThermobifida fusca (strain YX)
    Taxonomic identifieri269800 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
    ProteomesiUP000000434: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Leucine--tRNA ligasePRO_0000334834Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269800.Tfu_2156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47MY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi53 – 6311"HIGH" regionAdd
    BLAST
    Motifi593 – 5975"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiEICAPEQ.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q47MY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVSGDQTT SGSYDVRALQ EKWQARWAKE NPFTASEDPA DPRPRRYVLD    50
    MFPYPSGDLH MGHAEAFAIG DVIARYHFAR GENVLHPIGW DSFGLPAENA 100
    AIKHNFHPAE WTYTNIETQA ESFRRYAISL DWSRRLHTSD PEYYRWNQWF 150
    FLRFFERGLA YRKDGLVNWC PKDQTVLANE QVIQGKCERC GTEVERRALN 200
    QWYFKITDYA QRLLDDMEQL EGKWPERVLT MQRNWIGRSE GADVQFTIEG 250
    REEPVTVFTT RPDTLYGATF FVVAPDSPLA DELCAPEQRE AFEAYRTQVS 300
    KLSDIERQST EREKTGVFLG RYAINPVNGE RIPVWAADYV LADYGHGAIM 350
    AVPAHDQRDL DFARKFNLPV RVVVDTGEPD PAETGIATPG EGTLINSGPL 400
    NGLSKSEAIP RIIEILTERG TGKAAVNYRL RDWLVSRQRF WGTPIPIIHC 450
    PECGEVPVPD EELPVRLPDL RGAALAPKGV SPLAAATDWV NVSCPRCGGP 500
    AKRDTDTMDT FVDSSWYFLR YCSPNLDTAP FDQEKVAKWG PIDQYVGGVE 550
    HAILHLLYSR FFTKVLYDMG MVPFTEPFVR LLNQGQVINQ GKAMSKSLGN 600
    GVDLGQEIDR YGVDAVRLTM VFAGPPEEDI DWADVSPGAS VKFLNRAYRV 650
    MAEAAAASAP GVDPATGDLA LRRMTHQTLA KVTEAVEAQR FNVAIARIME 700
    LVTAARRAID SGPGAADPAV REAAEVIAIT LGLFAPYVAE EGWEMLGHTG 750
    SVSVGTWREP DPALLVQESV TCVVQVASKV RDKLQVSPDI SAEELERLAL 800
    ASEKVQNHIA GREIRRIVVR EPKLVNIVVA 830
    Length:830
    Mass (Da):92,640
    Last modified:September 13, 2005 - v1
    Checksum:i1A44B3A2BAE1EACE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000088 Genomic DNA. Translation: AAZ56189.1.
    RefSeqiWP_011292579.1. NC_007333.1.
    YP_290212.1. NC_007333.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ56189; AAZ56189; Tfu_2156.
    GeneIDi3581446.
    KEGGitfu:Tfu_2156.
    PATRICi23904974. VBITheFus33945_2313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000088 Genomic DNA. Translation: AAZ56189.1 .
    RefSeqi WP_011292579.1. NC_007333.1.
    YP_290212.1. NC_007333.1.

    3D structure databases

    ProteinModelPortali Q47MY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269800.Tfu_2156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ56189 ; AAZ56189 ; Tfu_2156 .
    GeneIDi 3581446.
    KEGGi tfu:Tfu_2156.
    PATRICi 23904974. VBITheFus33945_2313.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi EICAPEQ.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TFUS269800:GI42-2171-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YX.

    Entry informationi

    Entry nameiSYL_THEFY
    AccessioniPrimary (citable) accession number: Q47MY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3