Q47MD9 (Q47MD9_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Ordered Locus Names:

Tfu_2350

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL AAZ56383.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q47MD9 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2920188865D16D0D	FASTA	353	37,383
	10 20 30 40 50 60 MSRTNDTRVV SYQPLVAPHD LLAELPMGPE RTALVEEARA EVKKVLDGED DRLLVVVGPC 70 80 90 100 110 120 SVHDPESALD YARRLKALIP SVSSELCVVM RVYFEKPRTT LGWKGLINDP GLDGSFDVHR 130 140 150 160 170 180 GLRTARKLLL DIGSLGVPAG TEFLDPITPQ YIADAVTWGA IGARTTESQV HRQLSSGLSM 190 200 210 220 230 240 PVGFKNGTDG NVQVAVDACR AAASSHTFFG VDPSGSGAVV STSGNPDCHV ILRGGRSGPN 250 260 270 280 290 300 YDADSVAAAL DTIEAAGLPR RLMIDASHAN SGKDHLRQPG VAQAIAAQVA EGQTGIIGVM 310 320 330 340 350 LESFLVPGAQ KLGDPAKLTY GQSITDKCMG WETTEEVLAH LADAVRSRRK ATS

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ56383.1.
RefSeq	YP_290406.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47MD9.
SMR	Q47MD9. Positions 6-349.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47MD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3581231.
GenomeReviews	Gene locus Tfu_2350 in contig CP000088_GR.
KEGG	tfu:Tfu_2350.
NMPDR	fig|269800.4.peg.2474.
PATRIC	23905398. VBITheFus33945_2517.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0722.
HOGENOM	HBG670536.
OMA	MDNSFKL.
PhylomeDB	Q47MD9.
ProtClustDB	PRK09261.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_2350-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q47MD9_THEFY

Accession

Primary (citable) accession number: Q47MD9

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)