Q47MD8 (Q47MD8_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase HAMAP MF_00259 RuleBase RU003981
EC=2.1.2.10 HAMAP MF_00259 RuleBase RU003981

Alternative name(s):
Glycine cleavage system T protein HAMAP MF_00259

Gene names

Name:	gcvT HAMAP MF_00259
Ordered Locus Names:	Tfu_2351

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903
Sequence similarities	Belongs to the GcvT family. HAMAP MF_00259 RuleBase RU003980

Ontologies

Keywords
Molecular function	Aminotransferase HAMAP MF_00259 RuleBase RU003981 SAAS SAAS022903 Methyltransferase EMBL AAZ56384.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q47MD8 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: E73BA66329EC503E	FASTA	372	38,810
	10 20 30 40 50 60 MTQPPTSDAR TTPLYDTHVA SGATMVEFAG WLMPLRYRSE SAEHRAVRDA AGLFDLSHMG 70 80 90 100 110 120 EIRVHGPQAA DCLDYALVGQ LSTLAVGRAR YTMIVTEQGG VLDDLIVYRL ADDDYLVVAN 130 140 150 160 170 180 AANTGTVAAA LTERAAGFTA TITDETADYA LLALQGPQSA AILGPLTDVD LSALRPYAAQ 190 200 210 220 230 240 HGTVAGTAVL LSRTGYTGED GFEIYLRPGT AAPALWDTLV EAGQPHGLLP AGLAARDTLR 250 260 270 280 290 300 LEAGMPLYGN ELTAELTPYD AGLGRVVKLD KPGDFVGRAA LAARASSGPT QVLVGLVGRG 310 320 330 340 350 360 RRVPRKGYPV LRDGVPVGTV TSGAPSPTLG KPIAIAAVKA GTDLSSGAFA VDVRGRAEAV 370 DVVDLPFYRR TS

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ56384.1.
RefSeq	YP_290407.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47MD8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47MD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3581232.
GenomeReviews	Gene locus Tfu_2351 in contig CP000088_GR.
KEGG	tfu:Tfu_2351.
NMPDR	fig|269800.4.peg.2475.
PATRIC	23905400. VBITheFus33945_2518.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q47MD8.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_2351-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q47MD8_THEFY

Accession

Primary (citable) accession number: Q47MD8

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)