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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Thermobifida fusca (strain YX)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451UniRule annotation
Active sitei539 – 5391UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2583-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Tfu_2554Imported
OrganismiThermobifida fusca (strain YX)Imported
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2554.

Structurei

3D structure databases

ProteinModelPortaliQ47LT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47LT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRDSARQEM PDQLRRDVRL LGEMLGTVLA ESGGQDLLDD VERLRRAVIG
60 70 80 90 100
AREGTVEGKE ITELVASWPL ERAKQVARAF TVYFHLVNLA EEHHRMRALR
110 120 130 140 150
ERDDAATPQR ESLAAAVHSI REDAGPERLR ELIAGMEFHP VLTAHPTEAR
160 170 180 190 200
RRAVSTAIQR ISAQLERLHA AHPGSGAEAE ARRRLLEEID LLWRTSQLRY
210 220 230 240 250
TKMDPLDEVR TAMAAFDETI FTVIPEVYRS LDRALDPEGC GRRPALAKAF
260 270 280 290 300
VRYGSWIGGD RDGNPFVTHE VTREAITIQS EHVLRALENA CERIGRTHTE
310 320 330 340 350
YTGLTPPSAE LRAALSSARA AYPRLMQEII KRSPNEPHRQ LLLLAAERLR
360 370 380 390 400
ATRLRNADLG YPNPEAFLAD LRTVQESLAA AGAVRQAYGE LQNLIWQAET
410 420 430 440 450
FGFHLAELEI RQHSAVHAAA LKEIRAGGEL SERTEEVLAT LRVVAWIQER
460 470 480 490 500
FGVEACRRYI VSFTQSADDI AAVYELAEHA MPPGKAPILD VIPLFETGAD
510 520 530 540 550
LDAAPQVLDG MLRLPAVQRR LEQTGRRMEV MLGYSDSAKD VGPVSATLRL
560 570 580 590 600
YDAQARLAEW AREHDIKLTL FHGRGGALGR GGGPANRAVL AQAPGSVDGR
610 620 630 640 650
FKVTEQGEVI FARYGQRAIA HRHIEQVGHA VLMASTESVQ RRAAEAAARF
660 670 680 690 700
RGMADRIAEA AHAAYRALVD TEGFAEWFSR VSPLEELSEL RLGSRPARRS
710 720 730 740 750
AARGLDDLRA IPWVFAWTQT RVNLPGWYGL GSGLAAVDDL EALHTAYKEW
760 770 780 790 800
PLFASLLDNA EMSLAKTDRV IAERYLALGG RPELTEQVLA EYDRTRELVL
810 820 830 840 850
KVTRHTRLLE NRRVLSRAVD LRNPYVDALS HLQLRALEAL RTGEADRLSE
860 870
EDRNHLERLL LLSVNGVAAG LQNTG
Length:875
Mass (Da):97,467
Last modified:September 13, 2005 - v1
Checksum:iF98D315840D149B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56587.1.
RefSeqiYP_290610.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56587; AAZ56587; Tfu_2554.
GeneIDi3580116.
KEGGitfu:Tfu_2554.
PATRICi23905838. VBITheFus33945_2732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56587.1.
RefSeqiYP_290610.1. NC_007333.1.

3D structure databases

ProteinModelPortaliQ47LT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_2554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ56587; AAZ56587; Tfu_2554.
GeneIDi3580116.
KEGGitfu:Tfu_2554.
PATRICi23905838. VBITheFus33945_2732.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2583-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YXImported.

Entry informationi

Entry nameiQ47LT5_THEFY
AccessioniPrimary (citable) accession number: Q47LT5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.