Q47LS6 (Q47LS6_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540
Ordered Locus Names:	Tfu_2563

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 SAAS SAAS006330
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540 SAAS SAAS006330
Ligand	Metal-binding HAMAP MF_00540 SAAS SAAS006330 Zinc HAMAP MF_00540 SAAS SAAS006330
Molecular function	Hydrolase HAMAP MF_00540 SAAS SAAS006330 EMBL AAZ56596.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	211	1	Proton donor By similarity HAMAP MF_00540
	Metal binding	19	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	21	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	208	1	Zinc; catalytic By similarity HAMAP MF_00540
	Metal binding	302	1	Zinc; catalytic By similarity HAMAP MF_00540
	Binding site	21	1	Substrate By similarity HAMAP MF_00540
	Binding site	23	1	Substrate By similarity HAMAP MF_00540
	Binding site	181	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540
	Site	232	1	Important for catalytic activity By similarity HAMAP MF_00540

Sequences

	Sequence		Length	Mass (Da)
	Q47LS6 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: A54567E996603249	FASTA	367	40,371
	10 20 30 40 50 60 MDAKPTLEQI RRAPKVLLHD HLDGGLRPQT IVELADAAGY TDLPTDDPEE LGAWFVAAAN 70 80 90 100 110 120 SGSLERYLET FRHTVAVMQT REALERVAAE CVEDLAADGI VYAEVRYAPE QHLRGGLRLE 130 140 150 160 170 180 EVVEAVQAGF AEGVRRVAHR GAVIQVRTLL TAMRQAARSR EIAELVVRYR DEGVVGFDLA 190 200 210 220 230 240 GPEAGFPPSR HVDACTYLRQ QNAYLTIHAG EASGLPSIWE ALQWCGADRI GHGVRVVEDI 250 260 270 280 290 300 EAADEHLHGA RLGRLASYVR DKQIPLEICP SSNVQTGAAP SLEAHPIHLL HRLRFRVTVN 310 320 330 340 350 360 TDNRLLGGIT LSDEFAALVD TFGYGWDDLE SFTVNAMKSA FASFDERLVL VNGRIKPGFA QLKWGGR

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ56596.1.
RefSeq	YP_290619.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47LS6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47LS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3581490.
GenomeReviews	Gene locus Tfu_2563 in contig CP000088_GR.
KEGG	tfu:Tfu_2563.
NMPDR	fig|269800.4.peg.2526.
PATRIC	23905854. VBITheFus33945_2740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	PYYMAMN.
PhylomeDB	Q47LS6.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_2563-MONOMER.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q47LS6_THEFY

Accession

Primary (citable) accession number: Q47LS6

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)