Q47LG1 (Q47LG1_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP MF_01401

Gene names

Name:	msrA HAMAP MF_01401
Ordered Locus Names:	Tfu_2678

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP]

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569 EMBL AAZ56711.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	53	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q47LG1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 0EC4AF85CF02606F	FASTA	222	24,419
	10 20 30 40 50 60 MFGFVKTDMV DPAKALPGRD TPMPVPERHE VLGTPLAPPY PEHAQLADFG MGCFWGVERI 70 80 90 100 110 120 FWRLGAENGI ITTAAGYAGG YTPNPTYEEV CTGRTGHAEV VRVVFDPERI SYTDLLKVFW 130 140 150 160 170 180 ENHDPTQGMR QGNDVGTQYR SIILYHNEEQ RAAAEASRDA FQPVLTRMGY GPITTEIVPA 190 200 210 220 TPFYFAEPYH QQYLSEAKNP HGYCGVSGTG ATCPVGVART SG

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed: 17209016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ56711.1.
RefSeq	YP_290734.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47LG1.
SMR	Q47LG1. Positions 10-214.
ModBase	Search...
Protein-protein interaction databases
STRING	Q47LG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3578966.
GenomeReviews	Gene locus Tfu_2678 in contig CP000088_GR.
KEGG	tfu:Tfu_2678.
NMPDR	fig|269800.4.peg.2825.
PATRIC	23906108. VBITheFus33945_2860.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	SAIYCTT.
PhylomeDB	Q47LG1.
ProtClustDB	CLSK2769790.
Enzyme and pathway databases
BioCyc	TFUS269800:TFU_2678-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q47LG1_THEFY

Accession

Primary (citable) accession number: Q47LG1

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)