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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Thermobifida fusca (strain YX)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTFUS269800:G1G4Q-2758-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Tfu_2726
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002436341 – 430Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ47LB3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2726

Structurei

3D structure databases

ProteinModelPortaliQ47LB3
SMRiQ47LB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiVIAEACP
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q47LB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHLKSHEL FNRARSVIPG GVNSPVRAFK AVGGTPPFMV SGKGPYLTDA
60 70 80 90 100
DGNTYVDLIC SWGPLILGHA HPAVVEALAK AAAQGTSYGA PTEAEVELAE
110 120 130 140 150
EIVSRTPVEK VRLVNSGTEA TMSAIRLARG ATGRAKVVKF AGNYHGHVDA
160 170 180 190 200
LLAAAGSGVA TFALPDSPGV TGASAADTIV LPYNDIAAVE AAFAEAGDEI
210 220 230 240 250
ACVIAEACPA NMGVVPPRDG FNAKLREITA RHGALLILDE VLTGFRVSPS
260 270 280 290 300
GWYGLEGVAP DLMTFGKVMG GGLPAAAFGG RADLMDQLSP EGSVYQAGTL
310 320 330 340 350
SGNPLATAAG LATLRNATPE VYAHIDAAAA RVSAAVSEAL TAEGVPHRIQ
360 370 380 390 400
HGGNLFTVFF TDTEVVDFDG ARAQNTARYA AFFQAMLEQG VYLPPAAFEA
410 420 430
WFFSAAHDDA ALDRVVSALP AAAKAAAQVA
Length:430
Mass (Da):44,180
Last modified:September 13, 2005 - v1
Checksum:iB108CE9319ABA9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA Translation: AAZ56759.1
RefSeqiWP_011293149.1, NC_007333.1

Genome annotation databases

EnsemblBacteriaiAAZ56759; AAZ56759; Tfu_2726
KEGGitfu:Tfu_2726

Similar proteinsi

Entry informationi

Entry nameiGSA_THEFY
AccessioniPrimary (citable) accession number: Q47LB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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