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Protein

Homoserine O-acetyltransferase

Gene

metX

Organism
Thermobifida fusca (strain YX)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metX)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651NucleophileUniRule annotation
Active sitei329 – 3291UniRule annotation
Active sitei359 – 3591UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2860-MONOMER.
UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERithefy-q47l17. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Alternative name(s):
Homoserine O-trans-acetylaseUniRule annotation
Short name:
HTAUniRule annotation
Short name:
Homoserine transacetylaseUniRule annotation
Gene namesi
Name:metXUniRule annotation
Ordered Locus Names:Tfu_2822
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Homoserine O-acetyltransferasePRO_0000231887Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2822.

Structurei

3D structure databases

ProteinModelPortaliQ47L17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. HTA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47L17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHDTTPPLP ATGAWREGDP PGDRRWVELS EPLPLETGGE LPGVRLAYET
60 70 80 90 100
WGSLNEDRSN AVLVLHALTG DSHVVGPEGP GHPSPGWWEG IIGPGLALDT
110 120 130 140 150
DRYFVVAPNV LGGCQGSTGP SSTAPDGRPW GSRFPRITIR DTVRAEFALL
160 170 180 190 200
REFGIHSWAA VLGGSMGGMR ALEWAATYPE RVRRLLLLAS PAASSAQQIA
210 220 230 240 250
WAAPQLHAIR SDPYWHGGDY YDRPGPGPVT GMGIARRIAH ITYRGATEFD
260 270 280 290 300
ERFGRNPQDG EDPMAGGRFA VESYLDHHAV KLARRFDAGS YVVLTQAMNT
310 320 330 340 350
HDVGRGRGGV AQALRRVTAR TMVAGVSSDF LYPLAQQQEL ADGIPGADEV
360 370
RVIESASGHD GFLTEINQVS VLIKELLAQ
Length:379
Mass (Da):40,833
Last modified:September 13, 2005 - v1
Checksum:iC36D4B2717B941C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56855.1.
RefSeqiWP_011293245.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56855; AAZ56855; Tfu_2822.
KEGGitfu:Tfu_2822.
PATRICi23906394. VBITheFus33945_3001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56855.1.
RefSeqiWP_011293245.1. NC_007333.1.

3D structure databases

ProteinModelPortaliQ47L17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_2822.

Protein family/group databases

ESTHERithefy-q47l17. Homoserine_transacetylase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ56855; AAZ56855; Tfu_2822.
KEGGitfu:Tfu_2822.
PATRICi23906394. VBITheFus33945_3001.

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.
BioCyciTFUS269800:GI42-2860-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETX_THEFY
AccessioniPrimary (citable) accession number: Q47L17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.