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Q47KV5

- PANC_THEFY

UniProt

Q47KV5 - PANC_THEFY

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Protein
Pantothenate synthetase
Gene
panC, Tfu_2884
Organism
Thermobifida fusca (strain YX)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donor By similarity
Binding sitei68 – 681Beta-alanine By similarity
Binding sitei68 – 681Pantoate By similarity
Binding sitei166 – 1661Pantoate By similarity
Binding sitei189 – 1891ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATP By similarity
Nucleotide bindingi160 – 1634ATP By similarity
Nucleotide bindingi197 – 2004ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2926-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Tfu_2884
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeThermobifida
ProteomesiUP000000434: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Pantothenate synthetaseUniRule annotation
PRO_0000305567Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2884.

Structurei

3D structure databases

ProteinModelPortaliQ47KV5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47KV5-1 [UniParc]FASTAAdd to Basket

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MTQSTASAHK TPVVTRTAEE IQALRPQLGR LALVPTMGAL HTGHRSLIAQ    50
AREHAESVAV SIFVNPLQFG PNEDYDRYPR TFDHDLRVCA EEGVDVVFAP 100
TVDVMYPDAD GDSLGQIVTV DPGSMGRVLE GEFRPGFFHG VLTVVNKLFN 150
LIRPDVAVFG QKDAQQLAVV RRMVRDLCLP VTIVAAPTVR DPDGLATSSR 200
NVYLSAEERA SALALSKALF AGADAASSGP AAVLAAARAI LSEAARATPP 250
VSVDYLALVD PTTFTEVGDD YRGDAVLAVA AWVGETRLID NVPLTL 296
Length:296
Mass (Da):31,543
Last modified:September 13, 2005 - v1
Checksum:i1E1BB5AC186F9E6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56917.1.
RefSeqiYP_290940.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56917; AAZ56917; Tfu_2884.
GeneIDi3581789.
KEGGitfu:Tfu_2884.
PATRICi23906532. VBITheFus33945_3066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000088 Genomic DNA. Translation: AAZ56917.1 .
RefSeqi YP_290940.1. NC_007333.1.

3D structure databases

ProteinModelPortali Q47KV5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 269800.Tfu_2884.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ56917 ; AAZ56917 ; Tfu_2884 .
GeneIDi 3581789.
KEGGi tfu:Tfu_2884.
PATRICi 23906532. VBITheFus33945_3066.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci TFUS269800:GI42-2926-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YX.

Entry informationi

Entry nameiPANC_THEFY
AccessioniPrimary (citable) accession number: Q47KV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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