Q47KT7 (Q47KT7_THEFY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase HAMAP-Rule MF_00209
EC=3.6.1.1 HAMAP-Rule MF_00209

Alternative name(s):
Pyrophosphate phospho-hydrolase HAMAP-Rule MF_00209

Gene names

Name:	ppa HAMAP-Rule MF_00209
Ordered Locus Names:	Tfu_2902

Organism

Thermobifida fusca (strain YX) [Complete proteome] [HAMAP] EMBL AAZ56935.1

Taxonomic identifier

269800 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptosporangineae › Nocardiopsaceae › Thermobifida › Thermomonospora fusca

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP-Rule MF_00209
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00209.
Sequence similarities	Belongs to the PPase family. HAMAP-Rule MF_00209

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_00209
Ligand	Magnesium HAMAP-Rule MF_00209 Metal-binding HAMAP-Rule MF_00209
Molecular function	Hydrolase HAMAP-Rule MF_00209 EMBL AAZ56935.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	52	1	Magnesium 1 By similarity HAMAP-Rule MF_00209
	Metal binding	57	1	Magnesium 1 By similarity HAMAP-Rule MF_00209
	Metal binding	57	1	Magnesium 2 By similarity HAMAP-Rule MF_00209
	Metal binding	89	1	Magnesium 1 By similarity HAMAP-Rule MF_00209

Sequences

	Sequence		Length	Mass (Da)
	Q47KT7 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 316B72F327905D9E	FASTA	171	19,604
	10 20 30 40 50 60 MEFDVTIEIP KGERNKYEMD HETGRIRLDR MLFTSTSYPA DYGFIEGTLG DDGDPLDALV 70 80 90 100 110 120 LLKQPTFPGC MIRCRAIGMF RMRDEAGGDD KVLCVPATDP RMEHLRDIHH VNEFERLEIQ 130 140 150 160 170 HFFTVYKDLE PGKSVEGAIW VGRHEAEQEI KNSIKRAAES GQQHGAYFKL D

References

[1]

"Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX." Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M., DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A., Richardson P., Wilson D.B., Kyrpides N. J. Bacteriol. 189:2477-2486(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YX.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000088 Genomic DNA. Translation: AAZ56935.1.
RefSeq	YP_290958.1. NC_007333.1.
3D structure databases
ProteinModelPortal	Q47KT7.
SMR	Q47KT7. Positions 1-156.
ModBase	Search...
Protein-protein interaction databases
STRING	269800.Tfu_2902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ56935; AAZ56935; Tfu_2902.
GeneID	3581388.
KEGG	tfu:Tfu_2902.
PATRIC	23906568. VBITheFus33945_3084.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0221.
HOGENOM	HOG000236473.
KO	K01507.
OMA	MFRMRDE.
ProtClustDB	CLSK2769875.
Family and domain databases
Gene3D	3.90.80.10. 1 hit.
HAMAP	MF_00209. Inorganic_PPase.
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
PANTHER	PTHR10286. PTHR10286. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q47KT7_THEFY

Accession

Primary (citable) accession number: Q47KT7

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)