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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Thermobifida fusca (strain YX)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 2611D-inositol 3-phosphateUniRule annotation
Binding sitei40 – 401UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei95 – 9511D-inositol 3-phosphateUniRule annotation
Binding sitei128 – 12811D-inositol 3-phosphateUniRule annotation
Binding sitei152 – 15211D-inositol 3-phosphateUniRule annotation
Binding sitei172 – 17211D-inositol 3-phosphateUniRule annotation
Binding sitei246 – 2461UDP-GlcNAcUniRule annotation
Binding sitei251 – 2511UDP-GlcNAcUniRule annotation
Metal bindingi321 – 3211Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi322 – 3221Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi324 – 3241Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei334 – 3341UDP-GlcNAcUniRule annotation
Binding sitei342 – 3421UDP-GlcNAcUniRule annotation
Metal bindingi348 – 3481MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2955-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Tfu_2913
OrganismiThermobifida fusca (strain YX)
Taxonomic identifieri269800 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeThermobifida
Proteomesi
  • UP000000434 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434D-inositol 3-phosphate glycosyltransferasePRO_0000400168Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi269800.Tfu_2913.

Structurei

3D structure databases

ProteinModelPortaliQ47KS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 332UDP-GlcNAc bindingUniRule annotation
Regioni37 – 4261D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47KS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQTPGTEA QSQTVQPGRI AAISLHTSPL DQPGTGDAGG MNVYIVEVAK
60 70 80 90 100
RLAERGIAVD IFTRATSFEQ PPEVELAPGV TVRNIAAGPY GTLDKTALIN
110 120 130 140 150
YLCPFVHGML RAEAEHLGGS YDLVHTHYWL SGQAGWPVAR EWGVPLVHSM
160 170 180 190 200
HTMARVKNMS LAEGDTPEPE ERVRGEDALV ALADRLIANT DDEAAQLINY
210 220 230 240 250
YGASPSRVST VFPGVDLTTF TPGSRAESLR RLGLPEDTIL LLFVGRVQRL
260 270 280 290 300
KAPDVLLRAA ARLLELNPSL RDRLVVAVVG GQSGTGYREP WLLSDLADSL
310 320 330 340 350
GIADLVRLEP PCPRAELVHY YRAATVTVVP SHSESFGLVA VESQACGTPV
360 370 380 390 400
VAARVGGLPT AVRDGVSGVL IDGHDPHDYA NVLHRMITEP RWRERMGAAG
410 420 430
IHHASGLSWE STVDGLLAAY RDALHQCRLT VPCR
Length:434
Mass (Da):46,721
Last modified:September 13, 2005 - v1
Checksum:i4877B069B7B59343
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56946.1.
RefSeqiWP_011293336.1. NC_007333.1.

Genome annotation databases

EnsemblBacteriaiAAZ56946; AAZ56946; Tfu_2913.
KEGGitfu:Tfu_2913.
PATRICi23906590. VBITheFus33945_3095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000088 Genomic DNA. Translation: AAZ56946.1.
RefSeqiWP_011293336.1. NC_007333.1.

3D structure databases

ProteinModelPortaliQ47KS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269800.Tfu_2913.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ56946; AAZ56946; Tfu_2913.
KEGGitfu:Tfu_2913.
PATRICi23906590. VBITheFus33945_3095.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Enzyme and pathway databases

BioCyciTFUS269800:GI42-2955-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_THEFY
AccessioniPrimary (citable) accession number: Q47KS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.