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Reviewed, UniProtKB/Swiss-Prot Q47K40 (DCUP_DECAR)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: Daro_0032
OrganismDechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]
Taxonomic identifier159087 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

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Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023901

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3281Substrate By similarity
Site771Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q47K40-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 3A25ED4B2760E098

FASTA35539,370
        10         20         30         40         50         60 
MSRPKNDTFL RALLKEPTEY TPLWLMRQAG RYLPEYCETR KRAGNFLNLC KSPTMACEVT 

        70         80         90        100        110        120 
LQPLARYDLD AAILFSDILT VPDAMGLGLY FAEGEGPKFE RPLREEWAIN NLTVTDPYEH 

       130        140        150        160        170        180 
LGYVMDAVSE IRRALDNSVP LIGFSGSPYT LACYMVEGEG SSDFRNIKAM LYNRPDLLHR 

       190        200        210        220        230        240 
ILSVTADSVI AYLNAQIDSG AQAVMIFDTW GGSLSNAAYE EFSLQYMRRI VAGLKKEKDG 

       250        260        270        280        290        300 
QRIPSIVFTK NGGLWLEKIA DIGCDAVGLD WTIDIGEARR RVGDKVALQG NLDPNVLFAQ 

       310        320        330        340        350 
PEIVAAEAKK VLDSFGPANT GHVFNLGHGI SQFTPPESVT ALVEAVHSHS RLSRK

« Hide

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References

[1]"Complete sequence of Dechloromonas aromatica RCB."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000089 Genomic DNA. Translation: AAZ44791.1.
RefSeqYP_283261.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3567794.
GenomeReviewsGene locus Daro_0032 in contig CP000089_GR.
KEGGdar:Daro_0032.
NMPDRfig|159087.4.peg.136.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ47K40.
OMAQ47K40. VFTKGGG.

Enzyme and pathway databases

BioCycDARO159087:DARO_0032-MON.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_DECAR
AccessionPrimary (citable) accession number: Q47K40
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents