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Q47IX3

- Q47IX3_DECAR

UniProt

Q47IX3 - Q47IX3_DECAR

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

Daro_0451

Organism
Dechloromonas aromatica (strain RCB)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: InterPro
  3. phosphoribosylaminoimidazole carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation, LyaseImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDARO159087:GI5B-465-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Ordered Locus Names:Daro_0451Imported
OrganismiDechloromonas aromatica (strain RCB)Imported
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi159087.Daro_0451.

Structurei

3D structure databases

ProteinModelPortaliQ47IX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034029.
KOiK01589.
OMAiDCILEGW.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47IX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVKSAMILP PATLGMLGGG QLGRFFVSAA HELGYQVWVL DPDKNSPAGQ
60 70 80 90 100
IAERHFCVDY NDYAALDEFA AGCAAITTEF ENVPADTLDY LAKFVPVRPS
110 120 130 140 150
AAAVGICQNR IAEKSFLRDN GLPHGPFAAI RCEDDIRNAD ASLFPAILKV
160 170 180 190 200
ARFGYDGKGQ ATVHNREEAL VAFGQFKGEQ CVLEQRLTLD YEVSVVLARD
210 220 230 240 250
ERGRVACFPT GENQHTKGIL DVSIVPARTT ACVKSDAEEV AARIAEKLGY
260 270 280 290 300
IGTMGVEFFI SRGQLIVNEM APRPHNSGHY TIDACVTDQF EQQVRALCGL
310 320 330 340 350
PLGEPRAHSA SVMVNLLGDL WYDGETYREP DWAKLHAVPN LKLHLYGKHH
360 370 380
ARPGRKMGHF TVIGDNAEAV QKAALAARAA IGIRDE
Length:386
Mass (Da):42,057
Last modified:September 13, 2005 - v1
Checksum:i31964C1849260870
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45208.1.
RefSeqiYP_283678.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45208; AAZ45208; Daro_0451.
GeneIDi3568363.
KEGGidar:Daro_0451.
PATRICi21599508. VBIDecAro89105_0456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45208.1 .
RefSeqi YP_283678.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47IX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_0451.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ45208 ; AAZ45208 ; Daro_0451 .
GeneIDi 3568363.
KEGGi dar:Daro_0451.
PATRICi 21599508. VBIDecAro89105_0456.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034029.
KOi K01589.
OMAi DCILEGW.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci DARO159087:GI5B-465-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCBImported.

Entry informationi

Entry nameiQ47IX3_DECAR
AccessioniPrimary (citable) accession number: Q47IX3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3