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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 2 (folE2-2), GTP cyclohydrolase FolE2 1 (folE2-1)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically important1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1 (EC:3.5.4.16)
Gene namesi
Name:folE2-1
Ordered Locus Names:Daro_0489
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002894881 – 266GTP cyclohydrolase FolE2 1Add BLAST266

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_0489.

Structurei

3D structure databases

ProteinModelPortaliQ47IT5.
SMRiQ47IT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK01495.
OMAiPYSSTCP.
OrthoDBiPOG091H0MIO.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445. PTHR36445. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47IT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPENIFLP DVQAAADTRR LAIQSVGVKG LRYPLQLENA AGELTSTVAT
60 70 80 90 100
FAMSVGLPPE VKGTHMSRFV ELLEARTGPL TQVGLLRMMA DMLLRLDASS
110 120 130 140 150
GRIELAFPYF IRKMAPVSGV ESLLDYDATL IVDQRAWESA TLTLRVVAPV
160 170 180 190 200
TSLCPCSKKI SDYGAHNQRS HITLEARLRS PMSIEDLVRI AEEEASCEVF
210 220 230 240 250
GLLKRPDEKW VTERAYDNPK FVEDLVRDIA LRLMNEPRIA EWKVASENFE
260
SIHNHSAYAE LYGCNE
Length:266
Mass (Da):29,695
Last modified:September 13, 2005 - v1
Checksum:i33614D3D050A5D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ45246.1.
RefSeqiWP_011286255.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45246; AAZ45246; Daro_0489.
KEGGidar:Daro_0489.

Similar proteinsi

Entry informationi

Entry nameiGCH41_DECAR
AccessioniPrimary (citable) accession number: Q47IT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families