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Q47IT5

- GCH41_DECAR

UniProt

Q47IT5 - GCH41_DECAR

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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDARO159087:GI5B-504-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-1UniRule annotation
Ordered Locus Names:Daro_0489
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2 1PRO_0000289488Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_0489.

Structurei

3D structure databases

ProteinModelPortaliQ47IT5.
SMRiQ47IT5. Positions 21-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK01495.
OMAiIAMTACP.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47IT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPENIFLP DVQAAADTRR LAIQSVGVKG LRYPLQLENA AGELTSTVAT
60 70 80 90 100
FAMSVGLPPE VKGTHMSRFV ELLEARTGPL TQVGLLRMMA DMLLRLDASS
110 120 130 140 150
GRIELAFPYF IRKMAPVSGV ESLLDYDATL IVDQRAWESA TLTLRVVAPV
160 170 180 190 200
TSLCPCSKKI SDYGAHNQRS HITLEARLRS PMSIEDLVRI AEEEASCEVF
210 220 230 240 250
GLLKRPDEKW VTERAYDNPK FVEDLVRDIA LRLMNEPRIA EWKVASENFE
260
SIHNHSAYAE LYGCNE
Length:266
Mass (Da):29,695
Last modified:September 13, 2005 - v1
Checksum:i33614D3D050A5D12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45246.1.
RefSeqiYP_283716.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45246; AAZ45246; Daro_0489.
GeneIDi3570213.
KEGGidar:Daro_0489.
PATRICi21599588. VBIDecAro89105_0495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45246.1 .
RefSeqi YP_283716.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47IT5.
SMRi Q47IT5. Positions 21-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_0489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ45246 ; AAZ45246 ; Daro_0489 .
GeneIDi 3570213.
KEGGi dar:Daro_0489.
PATRICi 21599588. VBIDecAro89105_0495.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K01495.
OMAi IAMTACP.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DARO159087:GI5B-504-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiGCH41_DECAR
AccessioniPrimary (citable) accession number: Q47IT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3