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Q47IT5

- GCH41_DECAR

UniProt

Q47IT5 - GCH41_DECAR

Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDARO159087:GI5B-504-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2-1UniRule annotation
    Ordered Locus Names:Daro_0489
    OrganismiDechloromonas aromatica (strain RCB)
    Taxonomic identifieri159087 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
    ProteomesiUP000000550: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266GTP cyclohydrolase FolE2 1PRO_0000289488Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi159087.Daro_0489.

    Structurei

    3D structure databases

    ProteinModelPortaliQ47IT5.
    SMRiQ47IT5. Positions 21-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK01495.
    OMAiIAMTACP.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q47IT5-1 [UniParc]FASTAAdd to Basket

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    MNAPENIFLP DVQAAADTRR LAIQSVGVKG LRYPLQLENA AGELTSTVAT    50
    FAMSVGLPPE VKGTHMSRFV ELLEARTGPL TQVGLLRMMA DMLLRLDASS 100
    GRIELAFPYF IRKMAPVSGV ESLLDYDATL IVDQRAWESA TLTLRVVAPV 150
    TSLCPCSKKI SDYGAHNQRS HITLEARLRS PMSIEDLVRI AEEEASCEVF 200
    GLLKRPDEKW VTERAYDNPK FVEDLVRDIA LRLMNEPRIA EWKVASENFE 250
    SIHNHSAYAE LYGCNE 266
    Length:266
    Mass (Da):29,695
    Last modified:September 13, 2005 - v1
    Checksum:i33614D3D050A5D12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ45246.1.
    RefSeqiYP_283716.1. NC_007298.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ45246; AAZ45246; Daro_0489.
    GeneIDi3570213.
    KEGGidar:Daro_0489.
    PATRICi21599588. VBIDecAro89105_0495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000089 Genomic DNA. Translation: AAZ45246.1 .
    RefSeqi YP_283716.1. NC_007298.1.

    3D structure databases

    ProteinModelPortali Q47IT5.
    SMRi Q47IT5. Positions 21-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 159087.Daro_0489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ45246 ; AAZ45246 ; Daro_0489 .
    GeneIDi 3570213.
    KEGGi dar:Daro_0489.
    PATRICi 21599588. VBIDecAro89105_0495.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K01495.
    OMAi IAMTACP.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DARO159087:GI5B-504-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
      Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
      BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RCB.

    Entry informationi

    Entry nameiGCH41_DECAR
    AccessioniPrimary (citable) accession number: Q47IT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3