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Q47IN0

- SYL_DECAR

UniProt

Q47IN0 - SYL_DECAR

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Protein
Leucine--tRNA ligase
Gene
leuS, Daro_0544
Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDARO159087:GI5B-561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Daro_0544
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligaseUniRule annotation
PRO_0000334747Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_0544.

Structurei

3D structure databases

ProteinModelPortaliQ47IN0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi629 – 6335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q47IN0-1 [UniParc]FASTAAdd to Basket

« Hide

MQDKYTPADI ERAAQQHWDK TGAARAVEDA TKPKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VLSRFHKMQG YNVLQPMGWD AFGMPAENAA LQNNVPPAGW 100
TYSNIDYMRQ QLKSLGFAID WEREFATCTP EYYRWEQWLF TRLYEKGLVY 150
KKLGTVNWDP VDHTVLANEQ VIDGRGWRSG ALIEKREIPM YYMKITAYAE 200
ELLSELDNLP GWPEQVRLMQ KNWIGKSTGV RFAFPLADNP DEKLWVFTTR 250
ADTIMGVTFV AVAAEHPLAT KAAANNPELA AFIEECKKGG VAEADIATME 300
KKGMPTGIYV THPLTGQQVE VWVGNYVLMS YGDGAVMAVP AHDERDFAFA 350
LKYNLPIKQV VAVDGETAFS HEAWAEWYAD KAKGKLVNSG KYDGLGYEAA 400
VDAIAADLAA KNLGDKKVQF RLRDWGISRQ RYWGCPIPII HCKTCGDVPV 450
PDDQLPVVLP ENVEITGAGS PLAKMPEFYE CQCPKCGGDA RRETDTMDTF 500
FESSWYFLRY ACPDNTTAMV DERVAYWCKG GIDQYIGGIE HAILHLLYSR 550
FFTKLMRDVG LIGDLGEPFA NLLTQGMVVA PTFYRELDGG KKQWINPADV 600
DVVTDERGRP TGATLKTDGL PVVIGGTEKM SKSKNNGVDP QALIDQYGAD 650
TARLFIMFAS PPDQSLEWSD AGVEGAYRFL RRLWKTTYDH LQAGLVAAST 700
SNDGLSSAQA DLRRKLHQTM GKVADDYGRR KQFNTAIAAV MELLNAYDKC 750
DLKDAAGRAL AQESLESIAL LLFPIVPHIG QALYAQLRPG ADAGNAAFPK 800
ADPAALKQDE IELMVQVNGK LRGAIRVSAE ADKATIEATA LANEDAIKFM 850
EGKPAKKVIV VPGRLVNIVA 870
Length:870
Mass (Da):96,514
Last modified:May 20, 2008 - v2
Checksum:i47B018626FEE15DB
GO

Sequence cautioni

The sequence AAZ45301.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45301.1. Different initiation.
RefSeqiYP_283771.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45301; AAZ45301; Daro_0544.
GeneIDi3570057.
KEGGidar:Daro_0544.
PATRICi21599700. VBIDecAro89105_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000089 Genomic DNA. Translation: AAZ45301.1 . Different initiation.
RefSeqi YP_283771.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47IN0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 159087.Daro_0544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ45301 ; AAZ45301 ; Daro_0544 .
GeneIDi 3570057.
KEGGi dar:Daro_0544.
PATRICi 21599700. VBIDecAro89105_0550.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DARO159087:GI5B-561-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiSYL_DECAR
AccessioniPrimary (citable) accession number: Q47IN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi