Reviewed,
UniProtKB/Swiss-Prot Q47HM4 (MHPB1_DECAR)
Last modified
June 16, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase 1 EC=1.13.11.16 | ||||
| Gene names |
| ||||
| Organism | Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 159087 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas |
Protein attributes
| Sequence length | 312 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively By similarity. |
| Catalytic activity | 3-(2,3-dihydroxyphenyl)propanoate + O2 = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. HAMAP MF_01653 2,3-dihydroxicinnamic acid + O2 = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. HAMAP MF_01653 |
| Cofactor | Fe2+ ion By similarity. |
| Pathway | Aromatic compound metabolism; 3-phenylpropionic acid degradation. HAMAP MF_01653 |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the ligB/mhpB extradiol dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | Iron |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP 3-carboxyethylcatechol 2,3-dioxygenase activityInferred from electronic annotation. Source: EC ferrous iron bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 312 | 312 | 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase 1 HAMAP MF_01653 | PRO_0000337648 | |||||
Sites | |||||||||
| Active site | 115 | 1 | Proton donor By similarity | ||||||
| Active site | 179 | 1 | Proton acceptor By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000089 Genomic DNA. Translation: AAZ45657.1. | |
| RefSeq | YP_284127.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3570003. |
| GenomeReviews | Gene locus Daro_0901 in contig CP000089_GR. |
| KEGG | dar:Daro_0901. |
| NMPDR | fig|159087.4.peg.1255. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q47HM4. |
| OMA | Q47HM4. PLNPEWD. |
Enzyme and pathway databases | |
| BioCyc | DARO159087:DARO_0901-MON. |
Family and domain databases | |
| HAMAP | MF_01653. [Tree] |
| InterPro | IPR004183. Xdiol_dOase_3B. [Graphical view] |
| Pfam | PF02900. LigB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MHPB1_DECAR | ||||||||
| Accession | Primary (citable) accession number: Q47HM4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


