ID   HEMH_DECAR              Reviewed;         367 AA.
AC   Q47HJ6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
DE   AltName: Full=Protoheme ferro-lyase;
DE   AltName: Full=Heme synthetase;
GN   Name=hemH; OrderedLocusNames=Daro_0929;
OS   Dechloromonas aromatica (strain RCB).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Dechloromonas.
OX   NCBI_TaxID=159087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K.,
RA   Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
RT   "Complete sequence of Dechloromonas aromatica RCB.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; CP000089; AAZ45685.1; -; Genomic_DNA.
DR   RefSeq; YP_284155.1; -.
DR   GeneID; 3570243; -.
DR   GenomeReviews; CP000089_GR; Daro_0929.
DR   KEGG; dar:Daro_0929; -.
DR   NMPDR; fig|159087.4.peg.1316; -.
DR   HOGENOM; Q47HJ6; -.
DR   OMA; Q47HJ6; TIEEIGM.
DR   BioCyc; DARO159087:DARO_0929-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00323; -; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; Ferrochelatase; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   ProDom; PD002792; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW   Metal-binding; Porphyrin biosynthesis.
FT   CHAIN         1    367       Ferrochelatase.
FT                                /FTId=PRO_1000079194.
FT   METAL       213    213       Iron (By similarity).
FT   METAL       294    294       Iron (By similarity).
SQ   SEQUENCE   367 AA;  41258 MW;  872B53AAF124D9F8 CRC64;
     MPRFLPEPPH RHGNPATTAV VLVNLGTPDA PTAPALKRYL KEFLSDPRVV EIPKPVWWLI
     LNGIILNIRP KKSAAKYASV WMPEGSPLRV HTERQAKLLK GLLGQRGHHL TVTSAMRYGS
     PSIPEVLAHL KAEGAKRILL VPMYPQYAAS TTATVVDEAA NWLTKIRNQP EMRFVRNFHD
     HEGYLAALEK SVRQHWQTNG SLGDNDRLLI SFHGLPKRSL DLGDPYFCEC HKTGRLLAER
     LNLKPEQFQI CFQSRFGKAE WLQPYTAPTL HEWGSKGVRR VDVICPGFVA DCLETLEEIA
     QEGRDDFLKA GGKEYHYIPA LNEDDAWIKA LADIAEQHLG GWSTKTAFDP HALETSAREA
     FKFGARA
//