Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q47HJ6 (HEMH_DECAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Daro_0929
OrganismDechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]
Taxonomic identifier159087 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Ferrochelatase HAMAP MF_00323
PRO_1000079194

Sites

Metal binding2131Iron By similarity
Metal binding2941Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47HJ6 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 872B53AAF124D9F8

FASTA36741,258
        10         20         30         40         50         60 
MPRFLPEPPH RHGNPATTAV VLVNLGTPDA PTAPALKRYL KEFLSDPRVV EIPKPVWWLI 

        70         80         90        100        110        120 
LNGIILNIRP KKSAAKYASV WMPEGSPLRV HTERQAKLLK GLLGQRGHHL TVTSAMRYGS 

       130        140        150        160        170        180 
PSIPEVLAHL KAEGAKRILL VPMYPQYAAS TTATVVDEAA NWLTKIRNQP EMRFVRNFHD 

       190        200        210        220        230        240 
HEGYLAALEK SVRQHWQTNG SLGDNDRLLI SFHGLPKRSL DLGDPYFCEC HKTGRLLAER 

       250        260        270        280        290        300 
LNLKPEQFQI CFQSRFGKAE WLQPYTAPTL HEWGSKGVRR VDVICPGFVA DCLETLEEIA 

       310        320        330        340        350        360 
QEGRDDFLKA GGKEYHYIPA LNEDDAWIKA LADIAEQHLG GWSTKTAFDP HALETSAREA 


FKFGARA

« Hide

References

[1]"Complete sequence of Dechloromonas aromatica RCB."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000089 Genomic DNA. Translation: AAZ45685.1.
RefSeqYP_284155.1. NC_007298.1.

3D structure databases

ProteinModelPortalQ47HJ6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ47HJ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3570243.
GenomeReviewsGene locus Daro_0929 in contig CP000089_GR.
KEGGdar:Daro_0929.
NMPDRfig|159087.4.peg.1316.
PATRIC21600488. VBIDecAro89105_0928.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBQ47HJ6.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycDARO159087:DARO_0929-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_DECAR
AccessionPrimary (citable) accession number: Q47HJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents