Reviewed, UniProtKB/Swiss-Prot Q47HJ6 (HEMH_DECAR)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	Daro_0929

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX By similarity.
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Ferrochelatase HAMAP MF_00323		PRO_1000079194
Sites
	Metal binding	213	1	Iron By similarity
	Metal binding	294	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q47HJ6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 872B53AAF124D9F8	FASTA	367	41,258
	10 20 30 40 50 60 MPRFLPEPPH RHGNPATTAV VLVNLGTPDA PTAPALKRYL KEFLSDPRVV EIPKPVWWLI 70 80 90 100 110 120 LNGIILNIRP KKSAAKYASV WMPEGSPLRV HTERQAKLLK GLLGQRGHHL TVTSAMRYGS 130 140 150 160 170 180 PSIPEVLAHL KAEGAKRILL VPMYPQYAAS TTATVVDEAA NWLTKIRNQP EMRFVRNFHD 190 200 210 220 230 240 HEGYLAALEK SVRQHWQTNG SLGDNDRLLI SFHGLPKRSL DLGDPYFCEC HKTGRLLAER 250 260 270 280 290 300 LNLKPEQFQI CFQSRFGKAE WLQPYTAPTL HEWGSKGVRR VDVICPGFVA DCLETLEEIA 310 320 330 340 350 360 QEGRDDFLKA GGKEYHYIPA LNEDDAWIKA LADIAEQHLG GWSTKTAFDP HALETSAREA FKFGARA

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000089 Genomic DNA. Translation: AAZ45685.1.
RefSeq	YP_284155.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3570243.
GenomeReviews	Gene locus Daro_0929 in contig CP000089_GR.
KEGG	dar:Daro_0929.
NMPDR	fig|159087.4.peg.1316.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q47HJ6.
OMA	Q47HJ6. TIEEIGM.
Enzyme and pathway databases
BioCyc	DARO159087:DARO_0929-MON.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_DECAR

Accession

Primary (citable) accession number: Q47HJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)