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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179UniRule annotation1
Active sitei205UniRule annotation1
Active sitei301UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:Daro_1148
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254561 – 359Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_1148.

Structurei

3D structure databases

ProteinModelPortaliQ47GX7.
SMRiQ47GX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini167 – 359CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiHAMAQTT.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47GX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKIKVMIV DDSALVRQVV AQALASDPGI EVTDVASDPI FALQKMKVRW
60 70 80 90 100
PDVLVIDIEM PRMDGITFLK KIMAEHPTPT VICSSLAEKG AQATFEALAA
110 120 130 140 150
GAVSIITKPK IGLKSFLEDA SNDIVQAVRS AARANLRALS ASANPAINRP
160 170 180 190 200
KLSADAMLST GSHRALERTT DQLVAIGTST GGTQALEAVL TRLPATAPGI
210 220 230 240 250
VIVQHMPEKF TAMFAERLDG LCQIEVREAR NGDRVLPGLA LIAPGGRHMM
260 270 280 290 300
LKRNGAQYVV DVADGPLINR HKPSVDVLFR SVAKFAGANA LGIIMTGMGD
310 320 330 340 350
DGARGMKEMH DAGAKTIAQD ESSCVVFGMP KEAIKLGGVD QTMPLQQIPG

AIVGYGKSC
Length:359
Mass (Da):37,941
Last modified:September 13, 2005 - v1
Checksum:i03A8EE95DB3EDF24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ45904.1.
RefSeqiWP_011286913.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45904; AAZ45904; Daro_1148.
KEGGidar:Daro_1148.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_DECAR
AccessioniPrimary (citable) accession number: Q47GX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome