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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36S-adenosyl-L-methionineUniRule annotation1
Binding sitei55S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei120S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:Daro_1227
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesAzonexaceaeDechloromonas
Proteomesi
  • UP000000550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002417081 – 232Ubiquinone biosynthesis O-methyltransferaseAdd BLAST232

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_1227.

Structurei

3D structure databases

ProteinModelPortaliQ47GP8.
SMRiQ47GP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiGTHDWEK.
OrthoDBiPOG091H064Z.

Family and domain databases

HAMAPiMF_00472. UbiG. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47GP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNADQAELD KFGELAHRWW DPNSEFKPLH DINPLRIDWI DQAISLAGKR
60 70 80 90 100
VLDVGCGGGL LSEGMAVRGA NVTGIDLSEK PLGVAKLHLL ETGQKVDYRK
110 120 130 140 150
ISVEELAEQM PGEFDAVTCL EMLEHVPNPS SVITACARLV KPGGQVFLST
160 170 180 190 200
LNRNPKSYLF AVIGAEYVLQ MLPKGTHDYA RFIKPSELAR WAKMANLEPE
210 220 230
ELVGMSYNPL TKKYSLGKDT SVNYLMRTIR HV
Length:232
Mass (Da):25,806
Last modified:September 13, 2005 - v1
Checksum:iE8D09C6AE2B4C954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ45983.1.
RefSeqiWP_011286992.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ45983; AAZ45983; Daro_1227.
KEGGidar:Daro_1227.

Similar proteinsi

Entry informationi

Entry nameiUBIG_DECAR
AccessioniPrimary (citable) accession number: Q47GP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2005
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families