ID   HLDD_DECAR              Reviewed;         332 AA.
AC   Q47GJ3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
DE            EC=5.1.3.20;
DE   AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE            Short=ADP-glyceromanno-heptose 6-epimerase;
DE            Short=ADP-hep 6-epimerase;
DE            Short=AGME;
GN   Name=hldD; OrderedLocusNames=Daro_1286;
OS   Dechloromonas aromatica (strain RCB).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Dechloromonas.
OX   NCBI_TaxID=159087;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K.,
RA   Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
RT   "Complete sequence of Dechloromonas aromatica RCB.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
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DR   EMBL; CP000089; AAZ46038.1; -; Genomic_DNA.
DR   RefSeq; YP_284508.1; -.
DR   GeneID; 3568745; -.
DR   GenomeReviews; CP000089_GR; Daro_1286.
DR   KEGG; dar:Daro_1286; -.
DR   NMPDR; fig|159087.4.peg.1014; -.
DR   HOGENOM; Q47GJ3; -.
DR   OMA; Q47GJ3; FGPNEYH.
DR   BioCyc; DARO159087:DARO_1286-MON; -.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; -; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; heptose_epim; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   CHAIN         1    332       ADP-L-glycero-D-manno-heptose-6-
FT                                epimerase.
FT                                /FTId=PRO_0000255727.
FT   NP_BIND      11     12       NADP (By similarity).
FT   NP_BIND      32     33       NADP (By similarity).
FT   NP_BIND      76     80       NADP (By similarity).
FT   REGION      202    205       Substrate binding (By similarity).
FT   ACT_SITE    140    140       Proton acceptor (By similarity).
FT   ACT_SITE    179    179       Proton acceptor (By similarity).
FT   BINDING      39     39       NADP (By similarity).
FT   BINDING      54     54       NADP (By similarity).
FT   BINDING      93     93       NADP (By similarity).
FT   BINDING     144    144       NADP (By similarity).
FT   BINDING     170    170       Substrate (By similarity).
FT   BINDING     171    171       NADP; via amide nitrogen (By similarity).
FT   BINDING     179    179       NADP (By similarity).
FT   BINDING     181    181       Substrate; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     188    188       Substrate (By similarity).
FT   BINDING     215    215       Substrate (By similarity).
FT   BINDING     294    294       Substrate (By similarity).
SQ   SEQUENCE   332 AA;  37231 MW;  DAB47A2FDE2C0554 CRC64;
     MYIVVTGAAG FIGSNIVKAL NERGITNIIA VDNLTKADKF KNLIDCDIVD YLDKNDFIER
     IQAGHFDGEI DAILHEGACS DTMETDGRYM MENNYRYSMI LLDWCLDQDV QFLYASSAAT
     YGSSGTFKEE RQYEGPLNVY GYSKFLFDQI VRQRLAQNPS SQIVGFRYFN VYGPRETHKG
     RMASVAFHNF NQFRADGKVK LFEGSHGYPD GDQQRDFVFV GDVAKVNLFF LDHPEKSGIF
     NLGSGRAQSF NDVAVAAVNG CRKARSESAL SLEELRAQGL LEYVAFPEAL KGKYQAFTQA
     DLGKLRAAGY DAPMATVEEG VSQYIEWLQR NV
//