Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q47GJ3 (HLDD_DECAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-L-glycero-D-manno-heptose-6-epimerase
EC=5.1.3.20
Alternative name(s):
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Short name=ADP-glyceromanno-heptose 6-epimerase
Short name=ADP-hep 6-epimerase
Short name=AGME
Gene names
Name:hldD
Ordered Locus Names:Daro_1286
OrganismDechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]
Taxonomic identifier159087 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity. HAMAP MF_01601

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity. HAMAP MF_01601

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity. HAMAP MF_01601

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity. HAMAP MF_01601

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_0000255727

Regions

Nucleotide binding11 – 122NADP By similarity
Nucleotide binding32 – 332NADP By similarity
Nucleotide binding76 – 805NADP By similarity
Region202 – 2054Substrate binding By similarity

Sites

Active site1401Proton acceptor By similarity
Active site1791Proton acceptor By similarity
Binding site391NADP By similarity
Binding site541NADP By similarity
Binding site931NADP By similarity
Binding site1441NADP By similarity
Binding site1701Substrate By similarity
Binding site1711NADP; via amide nitrogen By similarity
Binding site1791NADP By similarity
Binding site1811Substrate; via carbonyl oxygen By similarity
Binding site1881Substrate By similarity
Binding site2151Substrate By similarity
Binding site2941Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q47GJ3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: DAB47A2FDE2C0554

FASTA33237,231
        10         20         30         40         50         60 
MYIVVTGAAG FIGSNIVKAL NERGITNIIA VDNLTKADKF KNLIDCDIVD YLDKNDFIER 

        70         80         90        100        110        120 
IQAGHFDGEI DAILHEGACS DTMETDGRYM MENNYRYSMI LLDWCLDQDV QFLYASSAAT 

       130        140        150        160        170        180 
YGSSGTFKEE RQYEGPLNVY GYSKFLFDQI VRQRLAQNPS SQIVGFRYFN VYGPRETHKG 

       190        200        210        220        230        240 
RMASVAFHNF NQFRADGKVK LFEGSHGYPD GDQQRDFVFV GDVAKVNLFF LDHPEKSGIF 

       250        260        270        280        290        300 
NLGSGRAQSF NDVAVAAVNG CRKARSESAL SLEELRAQGL LEYVAFPEAL KGKYQAFTQA 

       310        320        330 
DLGKLRAAGY DAPMATVEEG VSQYIEWLQR NV

« Hide

References

[1]"Complete sequence of Dechloromonas aromatica RCB."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RCB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000089 Genomic DNA. Translation: AAZ46038.1.
RefSeqYP_284508.1. NC_007298.1.

3D structure databases

ProteinModelPortalQ47GJ3.
SMRQ47GJ3. Positions 3-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ47GJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3568745.
GenomeReviewsGene locus Daro_1286 in contig CP000089_GR.
KEGGdar:Daro_1286.
NMPDRfig|159087.4.peg.1014.
PATRIC21601216. VBIDecAro89105_1283.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0451.
HOGENOMHBG755066.
OMARRDFIYV.
PhylomeDBQ47GJ3.
ProtClustDBCLSK2525806.

Enzyme and pathway databases

BioCycDARO159087:DARO_1286-MONOMER.

Family and domain databases

HAMAPMF_01601. Heptose_epimerase.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK03274.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. Heptose_epim. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHLDD_DECAR
AccessionPrimary (citable) accession number: Q47GJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents