Q47F79 (LPXB_DECAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	Daro_1755

Organism

Dechloromonas aromatica (strain RCB) [Complete proteome] [HAMAP]

Taxonomic identifier

159087 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Dechloromonas › Dechloromonas aromatica

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255176

Sequences

	Sequence		Length	Mass (Da)
	Q47F79 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: E4BF34C68E6D804D	FASTA	382	42,578
	10 20 30 40 50 60 MGSAVRIAMV AGEASGDLLA SHLIAALKTH LPDAVFYGIG GPKMQAQGFD SWWPMEKLSV 70 80 90 100 110 120 MGYWDALKHY REIAGIRRQL KKRLLDLKPD IFIGVDAPDF NLGLETNLKA AGVRTIHYVS 130 140 150 160 170 180 PSIWAWRGGR VKKIAKAVNR VLALFPMEPA LYEKERVPVT YVGHPLADII PLQTSKQAVR 190 200 210 220 230 240 EKLSLPRDYP IFAMLPGSRQ GELAMMAETF VETAKIIRER HLPNAMFVVP LATRETRLQF 250 260 270 280 290 300 ELAIYNRQAG DVPFRLLFGH AQDALGAADV SLVASGTATL EAALIKRPMV ITYKIAKFSY 310 320 330 340 350 360 WLMKRMAYLP YVGLPNVLAG RFVVPEILQD EATPENLAEA LVKLYEDKEN AEAVEEAFTE 370 380 IHLQLRQNTA EKAARAVIEC LN

References

[1]

"Complete sequence of Dechloromonas aromatica RCB." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RCB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000089 Genomic DNA. Translation: AAZ46502.1.
RefSeq	YP_284972.1. NC_007298.1.
3D structure databases
ProteinModelPortal	Q47F79.
ModBase	Search...
Protein-protein interaction databases
STRING	159087.Daro_1755.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ46502; AAZ46502; Daro_1755.
GeneID	3568710.
KEGG	dar:Daro_1755.
PATRIC	21602152. VBIDecAro89105_1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018003.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	CLSK2768567.
Enzyme and pathway databases
BioCyc	DARO159087:GI5B-1834-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_DECAR

Accession

Primary (citable) accession number: Q47F79

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program