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Q47F79

- LPXB_DECAR

UniProt

Q47F79 - LPXB_DECAR

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Dechloromonas aromatica (strain RCB)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciDARO159087:GI5B-1809-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Daro_1755
OrganismiDechloromonas aromatica (strain RCB)
Taxonomic identifieri159087 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeDechloromonas
ProteomesiUP000000550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_0000255176Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi159087.Daro_1755.

Structurei

3D structure databases

ProteinModelPortaliQ47F79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q47F79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSAVRIAMV AGEASGDLLA SHLIAALKTH LPDAVFYGIG GPKMQAQGFD
60 70 80 90 100
SWWPMEKLSV MGYWDALKHY REIAGIRRQL KKRLLDLKPD IFIGVDAPDF
110 120 130 140 150
NLGLETNLKA AGVRTIHYVS PSIWAWRGGR VKKIAKAVNR VLALFPMEPA
160 170 180 190 200
LYEKERVPVT YVGHPLADII PLQTSKQAVR EKLSLPRDYP IFAMLPGSRQ
210 220 230 240 250
GELAMMAETF VETAKIIRER HLPNAMFVVP LATRETRLQF ELAIYNRQAG
260 270 280 290 300
DVPFRLLFGH AQDALGAADV SLVASGTATL EAALIKRPMV ITYKIAKFSY
310 320 330 340 350
WLMKRMAYLP YVGLPNVLAG RFVVPEILQD EATPENLAEA LVKLYEDKEN
360 370 380
AEAVEEAFTE IHLQLRQNTA EKAARAVIEC LN
Length:382
Mass (Da):42,578
Last modified:September 13, 2005 - v1
Checksum:iE4BF34C68E6D804D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ46502.1.
RefSeqiYP_284972.1. NC_007298.1.

Genome annotation databases

EnsemblBacteriaiAAZ46502; AAZ46502; Daro_1755.
GeneIDi3568710.
KEGGidar:Daro_1755.
PATRICi21602152. VBIDecAro89105_1740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000089 Genomic DNA. Translation: AAZ46502.1 .
RefSeqi YP_284972.1. NC_007298.1.

3D structure databases

ProteinModelPortali Q47F79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 159087.Daro_1755.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ46502 ; AAZ46502 ; Daro_1755 .
GeneIDi 3568710.
KEGGi dar:Daro_1755.
PATRICi 21602152. VBIDecAro89105_1740.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci DARO159087:GI5B-1809-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation."
    Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G., Lapidus A.
    BMC Genomics 10:351-351(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RCB.

Entry informationi

Entry nameiLPXB_DECAR
AccessioniPrimary (citable) accession number: Q47F79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3